Studies on Pyrimidine Derivatives. XXVII. Synthesis of 2- and 4-Pyrimidinyl Ketones by Means of the Hydration of Alkynylpyrimidines
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概要
- 論文の詳細を見る
In the palladium-catalyzed cross-coupling reaction of halopyrimidines with terminal acetylenes, 2- and 4-chloropyrimidines can be used as starting compounds, though their reactivity is inferior to that of 2- and 4-iodopyrimidines. The conversion of the 2- and 4-alkynylpyrimidines thus obtained into the corresponding pyrimidinylmethyl ketones was successfully achieved by consecutive treatment with piperidine and oxalic acid dihydrate.
- 社団法人日本薬学会の論文
- 1982-05-25
著者
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坂本 尚夫
Pharmaceutical Institute, Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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丹治 健一
Pharmaceutical Institute, Tohoku University
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丹治 健一
School Of Food & Nutritional Sciences University Of Shizuoka
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坂本 尚夫
Pharmaceutical Institute Tohoku University
関連論文
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- Studies on Pyrimidine Derivatives. XXX. The Palladium-Catalyzed Cross-Coupling Reaction of Iodopyrimidines with Terminal Olefinic Compounds
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- Studies on Pyrimidine Derivatives. X. Coupling Reaction of 5-Halopyrimidines with Olefinic Compounds in the Presence of Palladium Acetate and Triphenylphosphine
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