Studies on Pyrimidine Derivatives. IX. Coupling Reaction of Monosubstituted Acetylenes with Iodopyrimidines
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概要
- 論文の詳細を見る
The pyrimidine derivatives containing an acetylenic side chain were synthesized by means of the reaction of alkyl-(or phenyl) acetylenes with twelve kinds of 2-, 4-, and 5-iodopyrimidines in the presence of a palladium triphenylphosphine complex in satisfactory yields. When propargyl alcohol was used, the reaction exhibited the tendency of decreasing the yield. The reaction readily proceeded in both 2,4-diiodo- and 4,6-diiodo-pyrimidines to give the corresponding dialkynyl derivatives. This acetylene coupling reaction was applicable to the synthesis of the 4-quinazoline derivatives.
- 社団法人日本薬学会の論文
- 1978-12-25
著者
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江戸 清人
Pharmaceutical Institute Tohoku University
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坂本 尚夫
Pharmaceutical Institute, Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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