Studies on Ketene and Its Derivatives. XXXII. Reactions of α, β-Unsaturated Acid Anhydride with β-Aminocrotonamide and Related Compounds
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概要
- 論文の詳細を見る
Acylation of β-aminocrotonamide (I) with α, β-unsaturated acid anhydride (e. g. acrylic, crotonic and methacrylic anhydrides) afforded 2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxamide derivatives (IV), which were easily dehydrogenated by heating with Pd-black to give 2-methyl-6-oxo-1,6-dihydropyridine-3-carboxamides. Similarly, acylation of primary enamines such as ethyl β-aminocrotonate (XIa), 4-amino-3-penten-2-on (XIb), 2-amino-1-propenyl phenyl ketone (XIc), and 2-aminocrotononitrile (XId) with acrylic anhydride afforded 5-substituted-6-methyl-3,4-dihydro-2-pyridones (XII), which were given by the reaction of the primary enamines (XI) with ethyl acrylate in the presence of sodium ethoxide.
- 公益社団法人日本薬学会の論文
- 1969-12-25
著者
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山中 宏
Pharmaceutical Institute, Tohoku University
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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川又 淳司
Pharmaceutical Institute Tohoku University
関連論文
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- Studies on Pyrimidine Derivatives. XXX. The Palladium-Catalyzed Cross-Coupling Reaction of Iodopyrimidines with Terminal Olefinic Compounds
- Studies on Quinoline and Isoquinoline Derivatives. II. Coupling Reaction of Haloquinolines and Haloisoquinolines with Monosubstituted Acetylenes in the Presence of Palladium Complex
- Studies on Pyrimidine Derivatives. X. Coupling Reaction of 5-Halopyrimidines with Olefinic Compounds in the Presence of Palladium Acetate and Triphenylphosphine
- Studies on Pyrimidine Derivatives. IX. Coupling Reaction of Monosubstituted Acetylenes with Iodopyrimidines
- Studies on Pyrimidine Derivatives. VII. Nickel-Phosphine Complex-Catalyzed Grignard Coupling of Chloropyrimidines
- Studies on Ketene and Its Derivatives. XCV. Reaction of Diketene with Acyl Azides
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- Studies on Ketene and Its Derivatives. CI. Reaction of Diketene with 4-Amino-methylpyridine 1-Oxides
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- Antivertigo Agents. I. Structure-Activity Relationships of 2-(2-Aminoethyl) pyridines
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