Studies on Quinoline and Isoquinoline Derivatives. III. Reaction of Quinoline 1-Oxide with 2-Substituted Ethyl Acetimidates
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概要
- 論文の詳細を見る
In order to introduce a carbon substituent to the α-position of the quinoline ring, the condensation of quinoline 1-oxide (VII) with the primary enamines, such as ethyl 2-ethoxycarbonyl-(IIIb), ethyl 2-benzoyl-(IIId), ethyl 2-cyanoacetimidate (IIIe), and 2-ethoxycarbonylacetamidine (IIIc), was investigated. The reaction of VII in the presence of benzoyl chloride afforded the following products : ethyl 2-ethoxycarbonyl-2-(2-quinolyl) acetimidate (VIII), 65% ; ethyl 2-benzoyl-2-(2-quinolyl) acetimidate (X), 54% ; ethyl 2-cyano-2-(2-quinolyl) acetimidate (XI), 29% ; ethyl 2-diaminomethylene-2-quinolylacetate (XII), 62%. The similar reaction proceeded in the case of isoquinoline 2-oxide.
- 公益社団法人日本薬学会の論文
- 1979-03-25
著者
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小川 茂
Pharmaceutical Institute Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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今野 昌悦
東北大学薬学部
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今野 昌悦
Pharmaceutical Institute, Tohoku University
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小松 美奈子
東北大学薬学部
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小松 美奈子
Pharmaceutical Institute, Tohoku University
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