3-Amino-4-methyl-2-pentenamide, 2-Amino-1-cyclohexene-1-carboxamideおよび3-Amino-2,4-diphenyl-2-butenamideの合成ならびにそれらを用いた4(3H)-Pyrimidone誘導体の合成
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概要
- 論文の詳細を見る
Three kinds of primary enaminic acid amide, 3-amino-4-methyl-2-pentenamide (VIII), 2-amino-1-cyclohexene-1-carboxamide (XIV), and 3-amino-2,4-diphenyl-2-butenamide (XX) were synthesized. Acylation of VIII, XIV, and XX to the corresponding N-acylamino compounds (XXI, XXIII, and XXV) and their treatment with sodium ethoxide afforded 2-substituted 6-isopropyl-4 (3H)-pyrimidone (XXII), 2-substituted 5,6,7,8-tetrahydro-4 (3H)-quinazolone (XXIV), and 2-substituted 6-benzyl-5-phenyl-4 (3H)-pyrimidone (XXVI), where the substituent R was CH_3,CH_2CH_3,CH_2CH_2CH_3,CH (CH_3)_2,or C_6H_5. Treatment of VIII with aromatic aldehyde, in the presence of sodium ethoxide, afforded 2-aryl-5-arylmethyl-6-isopropyl-4 (3H)-pyrimidone (XXVIII : R=C_6H_5,p-Cl-C_6H_4,p-CH_3O-C_6H_4,2-furyl).
- 公益社団法人日本薬学会の論文
- 1971-09-25
著者
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今野 昌悦
東北大学薬学部
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加藤 鉄三
東北大学 薬
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加藤 鉄三
東北大学医学部薬学科
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山中 宏
東北大学医学部薬学科
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今野 昌悦
東北大学医学部薬学科
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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