Studies on as-Triazine Derivatives. IX. Synthesis of 5-Substituted 1, 2, 4-Triazine Derivatives through an Addition Reaction and Subsequent Oxidation(Organic,Chemical)

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概要

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• The addition reactions of various nucleophiles to 6-methyl-3-phenyl-1, 2, 4-triazine (1) were investigated and a practical preparation of 1 was developed. The reactions showed many similarities to those of quinazoline (at the 4-position) and acridine (at the 9-position). The hitherto unknown compounds 5-cyano- (3), 5-carbamoyl- (5) and 5-phenacyl-6-methyl-3-phenyl-1, 2, 4-triazines (11c) were synthesized.

• 公益社団法人日本薬学会の論文
• 1987-04-25

著者

• 山中 宏

  Pharmaceutical Institute, Tohoku University

• 今野 昌悦

  東北大学薬学部

• 今野 昌悦

  Pharmaceutical Institute, Tohoku University

• 鷺 又市

  東北大学薬学部

• 大場 節哉

  Pharmaceutical Institute, Tohoku University

• 鷺 又市

  Pharmaceutical Institute, Tohoku University

• 大場 節哉

  Pharmaceutical Institute Tohoku University

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