Studies on Ketene and Its Derivatives. XLVII. Reaction of 2-Aminopyridine with Diketene

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概要

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• Reaction of diketene with 2-aminopyridine (Ia), 2-amino-4-methylpyridine (Ib), and 2-amino-3-methylpyridine (Ic) gave 2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one (IIIa), 2,8-dimethyl-4H-pyrido [1,2-a] pyrimidin-4-one (IIIb), and 2,9-dimethyl-4H-pyrido [1,2-a]-pyrimidin-4-one (IIIc), respectively. Isomeric 2-one derivatives, such as 4-methyl-2H-pyrido [1,2-a] pyrimidin-2-one (IVa) and 4,8-dimethyl-2H-pyrido [1,2-α] pyrimidin-2-one (IVb), were prepared by reaction of α-bromocrotonic acid with Ia and Ib, respectively. The differences were sufficiently great to permit mass, nuclear magnetic resonance, infrared and ultraviolet spectral data in a distinction of the structures between the 4-one (III) and 2-one derivatives (IV).

• 公益社団法人日本薬学会の論文
• 1972-01-25

著者

• 山中 宏

  Pharmaceutical Institute, Tohoku University

• 加藤 鉄三

  東北大学 薬

• 加藤 鉄三

  Pharmaceutical Institute Tohoku University

• 片桐 信弥

  Pharmaceutical Institute, Tohoku University

• 片桐 信弥

  Health Sci. Univ. Hokkaido Hokkaido Jpn

• 片桐 信弥

  Pharmaceutical Institute Tohoku University

• 増田 進一

  Pharmaceutical Institute, Tohoku University

• 増田 進一

  Pharmaceutical Institute Tohoku University

• 加藤 鉄三

  Pharmaceutical Institute. Tohoku University

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