Cross-coupling Reactions of Haloisoxazoles with Olefins and Acetylenes
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概要
- 論文の詳細を見る
3,5-Dimethyl-4-iodoisoxazole (1a) reacted with phenylacetylene with catalysis by palladium (II) chloride-triphenylphosphine complex to give 3,5-dimethyl-4-phenylethynyl-isoxazole (2a). When 1a was treated with styrene under similar conditions, 3,5-dimethyl-4-trans-styrylisoxazole (3a) was obtained. In contrast, the palladium-catalyzed crosscoupling reaction of 3-phenyl-5-bromoisoxazole (4) with styrene afforded 3,3'-diphenyl-5,5'-biisoxazole (6) as the main product, instead of the desired styryl compound (5a). However, 3-phenyl-5-phenylethynylisoxazole (7a) was obtained, as in the case of 1a, by the reaction of 4 with phenylacetylene. Some additional examples of these coupling reactions are also described.
- 公益社団法人日本薬学会の論文
- 1981-12-25
著者
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山中 宏
Pharmaceutical Institute, Tohoku University
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白岩 雅文
Pharmaceutical Institute, Tohoku University
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山本 恵津子
Pharmaceutical Institute Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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白岩 雅文
Pharmaceutical Institute Tohoku University
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