Studies on Pyrimidine Derivatives. II. Reaction of Some Dimethyl and Trimethyl-heteroaromatics with Ethyl Nitrite
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概要
- 論文の詳細を見る
Methyl groups at the 4-position of 2,4-dimethyl-, 2,4,6-trimethyl-pyridine, 2,4-dimethyl-, 2,4,6-trimethyl-pyrimidine, 2,4-dimethylquinoline, and 2,4-dimethylquinazoline were nitrosated selectively with ethyl nitrite in the presence of alkali amide in liquid ammonia to give the corresponding 4-aldoximes. On heating with phosphoryl chloride, the aldoximes were converted to 4-carbonitriles except 2-methylquinazoline-4-aldoxime which was sublimated with phosphorous pentoxide to afford 4-cyano-2-methylquinazoline. Related to these synthetic experiments, the hydrogen-deuterium exchange reaction of the methyl groups was examined by means of the NMR technique. The observed results did not contradict the direction of nitrosation of the testing compounds.
- 公益社団法人日本薬学会の論文
- 1977-07-25
著者
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山中 宏
Pharmaceutical Institute, Tohoku University
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阿部 弘之
Pharmaceutical Institute Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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平沼 英敏
Pharmaceutical Institute Tohoku University
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鎌田 厚子
Pharmaceutical Institute, Tohoku University
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鎌田 厚子
Pharmaceutical Institute Tohoku University
関連論文
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