Studies on Pyrimidine Derivatives. XXIV. Synthesis of 3-Substituted 1,2,4-Triazines by Nucleophilic Substitution

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概要

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• The potassium permanganate oxidation of 3-methylthio-5,6-diphenyl-as-triazine in the presence of a phase-transfer catalyst afforded 3-methylsulfonyl-5,6-diphenyl-as-triazine. The 3-sulfonyl-as-triazine readily reacted not only with active methylene compounds but also with methyl or methylene ketones under basic conditions, and 5,6-diphenyl-as-triazines containing a functionalized carbon substituent at the 3-position were obtained. Similarly, 2-substituted 4,6-dimethylpyrimidines were synthesized by the nucleophilic substitution of 4,6-dimethyl-2-phenylsulfonylpyrimidine with various ketones.

• 公益社団法人日本薬学会の論文
• 1982-01-25

著者

• 水柿 道直

  Pharmaceutical Institute Tohoku University

• 小川 茂

  Pharmaceutical Institute Tohoku University

• 山中 宏

  Pharmaceutical Institute, Tohoku University

• 今野 昌悦

  東北大学薬学部

• 今野 昌悦

  Pharmaceutical Institute, Tohoku University

• 横山 政明

  Pharmaceutical Institute, Tohoku University

• 買手 明子

  Pharmaceutical Institute, Tohoku University

• 山蔦 育子

  Pharmaceutical Institute, Tohoku University

• 横山 政明

  Pharmaceutical Institute Tohoku University

• 山蔦 育子

  Pharmaceutical Institute Tohoku University

• 買手 明子

  Pharmaceutical Institute Tohoku University

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