Separation and Some Characterizations of NADPH-Enoyl CoA Reductase (s) from Candida albicans
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概要
- 論文の詳細を見る
Two fractions containing NADPH-enoyl CoA reductase activities were isolated from crude extracts of Candida albicans. One fraction (Type-I) having larger molecular weight utilizes 5-hydroxyundec-cis-2-enoyl CoA, oct-cis-2-enoyl CoA and oct-trans-2-enoyl CoA as substrates with Km values of 2.5×10^<-6>M, 1.1×10^<-6>M and 5.0×10^<-7>M, respectively, while another fraction (Type-II) having smaller molecular weight utilizes these substrates with Km values of 3.0×10^<-6>M, 5.3×10^<-5>M and 1.0×10^<-5>M, respectively. This indicates that there exist comparable differences between these two in their affinities especially for the latter two substrates. Some characterizations, such as, effects of pH and of heat treatment on the activities of these reductase preparations were also investigated.
- 社団法人日本薬学会の論文
- 1974-11-25
著者
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水柿 道直
Pharmaceutical Institute Tohoku University
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内山 充
Pharmaceutical Institute, Tohoku University
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石館 光三
Pharmaceutical Institute, Tohoku University
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内山 充
Division of Drugs, National Institute of Hygienic Sciences
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内山 充
Division Of Drugs National Institute Of Hygienic Sciences
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石館 光三
Pharmaceutical Institute Tohoku University
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