^3H標識Mannanの生体内運命(第1報)

概要

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Metabolic fate of mannan, which is known as one of anti-timor polysaccharides, was investigated with ^3H-mannan in the mice. 1) After a single intraperitoneal injection of ^3H-mannan, the radioactivity was predominantly incorporated into the liver and spleen, indicating selective retention of the polysaccharide in reticuloendothelial system cells. The distributed radioactivity showed a maximum level during rather a long period between 6 and 15 hours and decreased slowly thereafter maintaining a high level even after 1 week. On the other hand, the level of radioactivity in the kidney and blood was low and dropped rapidly. 2) By the examination of the forms of the radioactive substance in the liver, using the gel filtration method, it was clarified that the radioactivity remained mainly in large-molecule fractions.
公益社団法人日本薬学会の論文
1972-12-25