マウス肝ミクロソームのチトクローム P-450 に対する有機リン殺虫剤
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概要
- 論文の詳細を見る
フェニトロチオン100mg/kgをマウス腹腔に注射すると肝ミクロソームのチトクロームP-450量の薬物代謝活性は2相性の変化を示す.プロトヘム量はやや減少するがチトクロームb_5量は影響をうけない.薬物代謝阻害剤のSKF-525Aで前処理したマウスでは, フェニトロチオン投与によるP-450の減少度が少なくなる.一方, P=S結合をもつ有機リン剤をミクロンソームとin vitroでインキュベートすると, NADPHの存在下に限りミクロソームのP-450が著明に減少する.このことは, 有機リン剤投与で初期に起るP-450の低下はS化合物の酸化的代謝と共役していることを示す.有機リン剤投与後24時間くらいでP-450量は平常に復するがCoCl_2の前処理によりこの回復が遅延する.このことは, P-450の回復およびそれにつづく増加現象にはヘム合成が関与していることを示すものである.
- 日本農薬学会の論文
- 1978-02-20
著者
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鈴木 康男
Pharmaceutical Institute, Tohoku University
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内山 充
National Institute of Hygienic Sciences
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吉田 武美
Pharmaceutical Institute Tohoku University
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本間 慶子
Pharmaceutical Institute Tohoku University
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内山 充
Division of Drugs, National Institute of Hygienic Sciences
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鈴木 康男
Pharmaceutical Institute Tohoku University
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内山 充
Division Of Drugs National Institute Of Hygienic Sciences
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鈴木 康男
Pharmaceutical Insitute Tohoku University
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