Optical Resolution of Drugs by Cyclodextrin Complexation
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概要
- 論文の詳細を見る
A simple method of optical resolution of racemic drugs was developed by a combination of cyclodextrin complexation and subsequent Sephadex gel chromatography. Chiral discrimination with cyclodextrins was assessed by circular dichroism measurement. The optical purities of enantiomers separated by this method were above 40% and 30% for warfarin and mandelic acid, respectively. Our results demonstrate the utility of this method for easy resolution of racemates.
- 社団法人日本薬学会の論文
- 1985-10-25
著者
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佐藤 幸夫
Faculty Of Pharmaceutical Sciences Tohoku University
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鈴木 康男
Pharmaceutical Institute, Tohoku University
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佐藤 幸夫
Pharmaceutical Institute, Tohoku University
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鈴木 康男
Pharmaceutical Institute Tohoku University
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佐藤 幸夫
東北大学薬学部
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Sato Yukio
Faculty Of Pharmaceutical Science Tohoku University
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鈴木 康男
Pharmaceutical Insitute Tohoku University
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