Hemoglobin Denaturation Caused by Surfactants
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概要
- 論文の詳細を見る
The properties of hemoglobin denaturation caused by two anionic surfactants (sodium dodecylsulfate and sodium lauroylmethyltaurate) were examined using spectrophotometry (multi-plate reader), circular dichroism (CD) and high-performance liquid chromatography (HPLC), and their denaturating action on hemoglobin and sorption to it were examined by various methods. Correlation and factorial analyses were applied to the experimental data and the following results were obtained : (1) High correlations were found among sorption, denaturation and α-helix content and the random structure of hemoglobin. (2) The α-helix of hemoglobin is randomized as the surfactants denature hemoglobin. (3) Factorial analysis indicates that there are two factors involved in hemoglobin denaturation, one related to the destruction of the α-helix and the other related to a change in the β-structure. These two factors are related to change in the environment around the heme group. (4) Destruction of the α-helix seems to be one of the causes of the eye irritation produced by anionic surfactants.
- 社団法人日本薬学会の論文
- 1995-04-15
著者
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佐藤 幸夫
Faculty Of Pharmaceutical Sciences Tohoku University
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鈴木 康男
Faculty of Pharmaceutical Sciences, Tohoku University
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林 俊克
Shiseido Research Center
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板垣 宏
Shiseido Research Center
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福田 敏夫
Shiseido Research Center
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田村 宇平
Shiseido Research Center
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林 俊克
(株)資生堂研究開発本部第一リサーチセンター
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鈴木 康男
Faculty Of Pharmaceutical Sciences Tohoku University
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板垣 宏
(株)資生堂研究開発本部第一リサーチセンター
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佐藤 幸夫
東北大学薬学部
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Sato Yukio
Faculty Of Pharmaceutical Science Tohoku University
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Fukuda T
Shiseido Research Center
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佐藤 幸夫
Faculty Of Pharmaceutical Science Tohoku University
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Itagaki H
Shiseido Research Center
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Suzuki Yasuo
Faculty Of Pharmaceutical Science Tohoku University
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