Interactions between Bacteriohopane-32,33,34,35-tetrol and Liposomal Membranes Composed of Dipalmitoylphosphatidylcholine

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概要

• 論文の詳細を見る

• The effects of bacteriohopane-32,33,34,35-tetrol (Tetrol), on liposomal membranes composed of dipalmitoyl-phosphatidylcholine (DPPC) were examined and compared with those of bacteriohopane-32-ol (Monol) and cholesterol (Chol) by means of ESR and NMR techniques. ^1H-NMR spectra of Tetrol-incorporated DPPC membranes showed splitting of the signals of the choline N-methyl resonance, whereas Monol-and Chol-incorporated membranes showed no splitting of signals above the transition temperature of DPPC. It was suggested that the incorporation of Tetrol affected only the fluidity near the polar head groups of the DPPC membranes. The characteristics of the interactions between Tetrol and membranes are due to the fact that in DPPC bilayers Tetrol and Monol have an inverted orientation contrary to Chol, and that the hydroxy groups of Tetrol suppress the hydrophobic interaction between DPPC molecules whereas the methyl groups of the hopanoid ring promote this.

• 社団法人日本薬学会の論文
• 1995-03-15

著者

• 佐藤 美洋

  北海道大学大学院薬学研究院

• 佐藤 幸夫

  Faculty Of Pharmaceutical Sciences Tohoku University

• 陳 戦松

  Faculty of Pharmaceutical Sciences, Tohoku University

• 鈴木 康男

  Faculty of Pharmaceutical Sciences, Tohoku University

• 中澤 亥三

  Nippon Del Monte Co.

• 鈴木 康男

  Faculty Of Pharmaceutical Sciences Tohoku University

• 陳 戦松

  Faculty Of Pharmaceutical Sciences Tohoku University

• Sato Y

  Osaka Prefecture University

• Suzuki Y

  Fukuoka Inst. Technol. Fukuoka

• Suzuki Y

  Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University

• Sato Y

  (present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Suzuki Y

  Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph

• 佐藤 嘉信

  Department Of Chemical Engineering University Of Osaka Prefecture

• 佐藤 幸夫

  Faculty Of Pharmaceutical Science Tohoku University

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