Measurement of Moisture Content by IR Sensor in Fluidized Bed Granulation. Effects of Operating Variables on the Relationship between Granule Moisture Content and Absorbance of IR Spectra
スポンサーリンク
概要
- 論文の詳細を見る
In this study, the validity of moisture measurement by an IR sensor was investigated in fluidized bed granulation. The effects of operating variables on the relationship between granule moisture content and the absorbance of IR spectra were examined experimentally. It was found that the air flow rate of purge air used for preventing powder adhesion, fluidizing air velocity, agitator rotational speed and spray mist size had no effect on the relationship. However, if the dampening speed was extremely low, the effects of fluidization air temperature and liquid flow rate on the relationship could be recognized. This was because the surface drying due to the extremely low dampening speed caused water to transfer from the inside to the surface. As a result, it can be concluded that the measurement of moisture content by an IR moisture sensor can be conducted with high accuracy, free of operating conditions, unless the granulation is conducted under an extremely low dampening speed.
- 公益社団法人日本薬学会の論文
- 1996-06-15
著者
-
佐藤 美洋
北海道大学大学院薬学研究院
-
SATO Yoshinobu
Department of Chemistry, Faculty of Science and Engineering, Sophia University
-
Sato Y
Osaka Prefecture University
-
Watano Satoru
Department of Chemical Engineering, Graduate School of Engineering, Osaka Prefecture University
-
Watano S
Osaka Prefecture University
-
Watano Satoru
Department Of Chemical Engineering Osaka Prefecture University
-
Watano Satoru
Department Of Chemical Engineering Graduate School Of Engineering Osaka Prefecture University
-
Sato Y
(present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
-
takashima hideo
Department of Cardiology, Fukuoka University School of Medicine
-
Takashima Hideo
Department Of Chemical Engineering Osaka Prefecture University
-
Takashima Hideo
Department Of Cardiology Fukuoka University Hospital School Of Medicine
-
YASUTOMO Teruhito
Taiho Pharmaceutical Co., Ltd.
-
MIYANAMI KEI
Department of Chemical Engineering, Osaka Prefecture University
-
佐藤 嘉信
Department Of Chemical Engineering University Of Osaka Prefecture
-
Miyanami K
Department Of Chemical Engineering Osaka Prefecture University
-
Miyanami Kei
Department Of Chemical Engineering Osaka Prefecture University
-
Sato Yoshinobu
Department Of Chemical Engineering Osaka Prefecture University
-
Yasutomo Teruhito
Control Department Taiho Pharmaceutical Co. Ltd.
-
Takashima Hideo
Department Of Cardiology Fukuoka University
-
Sato Yoshinobu
Department of Applied Physics,School of Engineering,Nagoya University
関連論文
- ルテナシクロペンテン中間体を経由するエンインの新規環化反応の開発
- Thermodynamic Effects of Hopanoids on Synthetic and Bacterial Phospholipid Membranes
- Interactions between Bacteriohopane-32,33,34,35-tetrol and Liposomal Membranes Composed of Dipalmitoylphosphatidylcholine
- ATOMIC FORCE MICROSCOPY OF DIMYRISTOYLPHOSPHATIDYLCHOLINE MEMBRANES
- Behaviors of the One-Electron Reduction Species of {RuNO}^6-Type Complexes. An Oxygen-Transfer Reaction Occurs in the Nitrosyl Site of cis-[Ru(NO^・)X(bpy)_2]^ (X=ONO_2 for n=1, X=CH_3CN, H_2O for n=2)({RuNO}^7-Type) to Give an Identical Nitro Species^
- Reductions of {RuNO}^6-Type Nitrosyls. Characteristics of the Two-Electron Reduction Species Isolated as a Complex Having a Formally Negatively Charged μ-Nitrosyl({RuNO}^8-{RuNO}^8) and the One-Electron Reduction Species Generated Electrochamically({RuNO}
- Synthesis and Electrochemical Behavior of the Complex Having μ_2-Nitrosyl Moiety, as a Two-Electron Reduction Species of a {RuNO}^6-Type Nitrosyl,[{Ru(μ_2-NO)}_2(2,2-bipy)_4]^
- A Hybrid Technique for Thickness-Map Visualization of the Hip Cartilages in MRI
- Synthesis and Hypnotic and Anti-Human Immunodeficiency Virus-1 Activities of N^3-Substituted 2'-Deoxy-2'-fluorouridines
- Synthesis and Antiviral Activity of Carbocyclic Oxetanocin Analogues(C-OXT-A, C-OXT-G) and Related Compounds. II
- Improvement of Dissolution Property of Poorly Water-Soluble Drug by Supercritical Freeze Granulation
- Improvement of Dissolution Property of Poorly Water-Soluble Drug by Novel Dry Coating Method Using Planetary Ball Mill
- Scale-Up of Agitation Fluidized Bed Granulation. III. Effects of Powder Feed Weight and Blade Angle on Granule Size, Density and Shape
- Scale-Up of Agitation Fluidized Bed Granulation. II. Effects of Scale, Air Flow Velocity and Agitator Rotational Speed on Granule Size, Size Distribution, Density and Shape
- Scale-Up of Agitation Fluidized Bed Granulation. I. Preliminary Experimental Approach for Optimization of Process Variables
- Measurement of Free and Bound Alcohol Metabolites and Methanol in Human Biological Samples : free and bound alcohol metabolites and methanol in acute alcohol administration
- Sleeping environments as risk factors of sudden infant death syndrome in Japan
- ルテナシクロペンテン中間体を経由するエンインの新規環化反応の開発
- Comparison of the Reaction of Benzylammonium N-Methylides with That of Benzylsulfonium S-Methylides
- Removal of Fine Powders from Film Surface. I. Effect of Electrostatic Force on the Removal Efficiency
- Effects of 3,3'-dihydroxy-α, β-diethylstilbene and 3,3', 4,5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks
- Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells
- Effect of meso-Hexestrol, a Synthetic Estrogen, on S-Tubulin
- Metabolism of 32-Oxo-24,25-dihydrolanosterols by Partially Purified Cytochrome P-450_ from Rat Liver Microsomes
- Metabolism of 24,25-Dihydrolanosterol Analogs by Partially Purified Cytochrome P-450_ from Rat Liver Microsomes
- Metabolism of 32-Hydroxylated 24,25-Dihydrolanosterols by Partially Purified Cytochrome P-450_ from Rat Liver Microsomes
- In Vitro Effects of Oxygenated Lanosterol Derivatives on Cholesterol Biosynthesis from 24,25-Dihydrolanosterol
- A Hybrid Technique for Thickness-Map Visualization of the Hip Cartilages in MRI
- Scale-Up of High Shear Granulation Based on Agitation Power
- Scale-Up of High Shear Granulation Based on the Internal Stress Measurement
- Scale-Up of Wet Kneading in a Novel Vertical High Shear Kneader
- Optimization and validation of an image processing system in fluidized bed granulation
- IR absorption characteristics of an IR moisture sensor and mechanism of water transfer in fluidized bed granulation
- Control Granule Growth in Fluidized Bed Granulation by an Image Processing System
- Measurement of Moisture Content by IR Sensor in Fluidized Bed Granulation. Effects of Operating Variables on the Relationship between Granule Moisture Content and Absorbance of IR Spectra
- Control of moisture content by adaptive fuzzy control in agitation fluidized bed granulation
- APPLICATION OF FUZZY LOGIC TO MOISTURE CONTROL IN FLUIDIZED BED GRANULATION
- Heat Transfer and the Mechanism of Drying in Agitation Fluidized Bed
- Evaluation of intraoral CCD camera for dental examination in forensic inspection
- Optically Active trans-Diethylstilbestrol Oxide Monomethyl Ether
- Synthesis and Anti-tumor Activity of a Fluorinated Analog of Medroxyprogesterone Acetate (MPA), 9α-Fluoromedroxyprogesterone Acetate (FMPA)
- 11 Pd触媒を用いる環形成反応を機軸とした(-)-Strychnineの全合成(口頭発表の部)
- SYNTHESIS OF A NEW POTENT ANTI-ANGIOGENIC AGENT, 17α-ACETOXY-9α-FLUORO-6α-METHYLPROGESTERONE
- Development of a Novel Compression Tester and Rheo-Mechanical Properties of Wet-Mass Powder.II : Effect of Moisture Content on the Rheo-Mechanical Properties
- Development of a Novel Compression Tester and Rheo-Mechanical Properties of Wet-Mass Powder.I : Effect of Kneading Time on the Rheo-Mechanical Properties
- Novel mechanochemical process for synthesis of magnetite nanoparticles using coprecipitation method
- Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed III : Effect of Scale, Agitator Rotational Speed and Blade Shape on Granule Properties and Development of a High Accuracy Scale-Up Theory
- Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed II. : A Proposal of a Rapid Dissolution Test for Evaluation of Bitter Taste of Ibuprofen
- Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed I. Optimum Formulation for Core Particles and Development of a Novel Friability Test Method
- Scale-Up of Agitation Fluidized Bed Granulation. IV. Scale-Up Theory Based on the Kinetic Energy Similarity
- Numerical analysis of similarities of particle behavior in high shear mixer granulators with different vessel sizes
- ローダサイクル中間体を経由する新規環化反応とその応用
- Ruthenium-Catalyzed ROM-RCM of Cyclopentene-yne. Conclse Synthesis of a Pyrrolizidine Derivative
- Synthesis of Bicyclic Heterocycles from Propargyl Esters Using a Palladium Catalyst Bearing a Bidentate Ligand
- ニッケル触媒を用いた[2+2+2]環化反応の開発とその応用
- ニッケル触媒を用いる1, 3-ジエンとカルボニル基との立体選択的環化反応の開発と有機合成への応用
- Total Synthesis of Prostaglandin F_ Using Nickel-Catalyzed Stereoselective Cyclization of 1,3-Diene and Tethered Aldehyde via Transmetalation of Nickelacycle with Diisobutylaluminum Acetylacetonate
- Reaction of N, N-Dialkyl-N-(trimethylsilyl)methyl-γ-substituted Allylammonium Salts with Cesium Fluoride
- 4 遷移金属錯体による炭素-炭素結合形成反応を鍵段階とした(-)-mesembrineの合成(口頭発表の部)
- Thio-Sugars III. Radical Catalyzed Thione-Thiol Rearrangement of Cyclic Thionocarbonates on a Pyranose Ring : Formation of cis-Arranged Cyclic Thiolcarbonates
- 38 ニッケル触媒による新規環化反応の開発及びそのプロスタノイド合成への利用(口頭発表の部)
- Direct Observation of the Orientational Fluctuations in a Tilted Smectic Liquid Crystal with a High-Speed TV Camera
- DNA analysis of neonatal human remains wrapped and kept in a vinyl bag for 15 years
- Thio-Sugars. I. Radical-Promoted Thione-Thiol Rearrangement of Cyclic Thionocarbonates : Synthesis of 5-Thioglucose
- Surface Modification of Food Fiber by Dry Particle Coating
- Solitary Thyroid Metastasis of Renal Clear Cell Carcinoma : Report of a Case
- 不斉Heck反応による多環式化合物の触媒的不斉合成
- Numerical Simulation of Film Coating Process in a Novel Rotating Fluidized Bed
- Scale-Up of Agitation Fluidized Bed Granulation by Neural Network
- Scale-Up of Agitation Fluidized Bed Granulation. V. Effect of Moisture Content on Scale-Up Characteristics
- Quantitative evaluation of kneading and extrusion processes by pressure transmission characteristics of wet kneaded masses
- On-line Monitoring of Granule Growth in High Shear Granulation by an Image Processing System
- Modeling of Agitation Fluidized Bed Granulation by Random Coalescence Model
- Heat Transfer and Granule Growth Rate in Fluidized Bed Granulation
- Mathematical Model in the Kinetics of Agitation Fluidized Bed Granulation. Effects of MOisture Content, Damping Speed and Operation Time on Granule Growth Rate
- COMPUTER SIMULATION OF AGITATION FLUIDIZED BED GRANULATION BY A TWO-DIMENSIONAL RANDOM ADDITION MODEL
- COMPUTER SIMULATION OF FLUIDIZED BED GRANULATION BY A TWO-DIMENSIONAL RANDOM COALESCENCE MODEL
- Drying of Granules in Agitation Fluidized Bed
- Development of a novel particle size control system for hammer milling
- Determination of Optimal Formulation for Extrusion Granulation by Compression Test of Wet Kneaded Mass
- Development of a Novel Vertical High Shear Kneader and Its Performance in Wet Kneading of Pharmaceutical Powders
- Quantitative Analysis of Water Dispersion Conditions and Pressure Transmission Characteristics of a Wet Kneaded Mass
- A method for process monitoring and determination of operational end-point by frequency analysis of power consumption in agitation granulation
- Removal of Fine Powders from Film Surface. II. Effect of Operating Parameters on the Removal Efficiency
- Scale-up methodology for tumbling ball mill based on impact energy of grinding balls using discrete element analysis
- Continuous Monitoring and Mechanism of Electrostatic Charge of Powder in Fluidized Bed Process
- Effect of Spray Mist Size on the Properties of Granules Prepared by Agitation Fluidized Bed Coating
- Preparation of Core Particles for Aqueous Film Coating Using Agitation Fluidized Bed
- Prediction of Granule Physical Property by a Novel Compression Energy of Wet Powder
- Development of a Novel Granular Detergent by Inorganic Solution Binder
- Development of a Novel Granular Detergent with an Interspersion Particle Comprising an Anionic Surfactant and a Polymeric Polycarboxalate
- Development of a High Active Surfactant and High Soluble Granular Detergent by Secondary Alkyl Sulfate
- Monitoring and Scale-Up of Static Electrification during Solid-Liquid Mixing
- Rheological Analysis and Quantitative Evaluation of Wet Kneaded Wax Matrix
- Influence of the Loss of the Occlusal Supporting Zone on the Head Position in Clenching
- Nickel-Promoted Carboxylation/Cyclization Cascade of Allenyl Aldehyde under an Atmosphere of CO2
- Measurement of Physical Strength of Pharmaceutical Extruded Pellets
- Development of a Novel Tablet Machine for a Tiny Amount of Powder and Evaluation of Capping Tendency
- In-Die Evaluation of Capping Tendency of Pharmaceutical Tablets Using Force-Displacement Curve and Stress Relaxation Parameter
- My impression of APT2000