Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed I. Optimum Formulation for Core Particles and Development of a Novel Friability Test Method
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概要
- 論文の詳細を見る
To prepare powdered medicines without bitter taste, film coating is required to cover the surface of core particles. In this study, effect of formulation and operating conditions of agitation fluidized bed on the core particle properties was investigated. In order to prevent breakage of the core particles during coating process, which sometimes causes variation of drug dissolution rate, addition of maltose syrup powder during the formulation process of the core particles was investigated. Also, a method for friability test in which the core particles were subjected to strong impact was proposed to evaluate strength of the core particles. The friability of the core particles determined by this test method correlated well with the actual friability of the particles during the coating process. Based on this result, we confirmed this novel friability test method could predict the core particle endurance during the coating process.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
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Watano Satoru
Department of Chemical Engineering, Graduate School of Engineering, Osaka Prefecture University
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Watano Satoru
Department Of Chemical Engineering Graduate School Of Engineering Osaka Prefecture University
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Nakagawa Yasuo
Oral Solid Formulation Laboratory Self Medication Laboratories Taisho Pharmaceutical Co. Ltd.
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Hamashita Tomohiro
Oral Solid Formulation R & D Laboratories Self Medication Business Taisho Pharmaceutical Co. Ltd
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AKETO Takao
Oral Solid Formulation, R & D Laboratories, Self Medication Business, Taisho Pharmaceutical Co., Ltd
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Aketo Takao
Oral Solid Formulation R & D Laboratories Self Medication Business Taisho Pharmaceutical Co. Ltd
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