Rheological Analysis and Quantitative Evaluation of Wet Kneaded Wax Matrix

概要

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The properties of the wet kneaded wax matrix were evaluated using a compression tester, whereby a newly proposed σ index for the plastic deformation was assessed in the pressure transmission diagram. The σ index was indicative of a characteristic of the plastic yield point in the rheological behavior, and presented an initial and abrupt deformation of wet kneaded mass when the wet kneaded mass was subjected to the pressure. The value of σ index was confirmed to decrease along with an increase in the plasticity of wet kneaded mass. The wet mass of wax matrix was prepared under various kneading time, and then extruded. The properties of the extruded granules such as pore volume, strength and dissolution were investigated. As a result, it was found that the σ index decreased with an increase in kneading time. The granules with small value of σ index showed few porosities, large strength and slow dissolution. It was demonstrated that the σ index linked the characteristics of wet kneaded mass to the dissolution and the other granule properties. Existence of this link was revealed by σ index evaluation relevant to the plasticity. The σ index could be a decisive criterion to permit an in-process evaluation of the kneading progress quantitatively, and also useful for anticipating the dissolution of the final granules roughly.
公益社団法人日本薬学会の論文
2004-05-01