Development of a Novel Compression Tester and Rheo-Mechanical Properties of Wet-Mass Powder.I : Effect of Kneading Time on the Rheo-Mechanical Properties
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概要
- 論文の詳細を見る
In our previous paper [Watano S., et al., Chem. Phram. Bull., 49(1), 64-68, (2001)], a compaction tester was developed to quantitatively evaluate the water dispersion condition of wet kneaded masses prepared by a paddle type kneader. It was also demonstrated that the physical properties of pellets prepared by extrusion granulation after the kneading could be well predicted by the vertical pressure transmission obtained through the compaction tester. However, in this compression tester, the vertical pressure transmission was just obtained and rheological and mechanical properties (so called rheo-mechanical properties) of wet mass-powder that should be the most important to determine the deformation process were not well studied. In this study, a novel compression tester, which can measure both vertical and radial pressure transmissions, has been developed. Based on the compression test, mechanical property (Young's modulus) and rheological property (effective internal friction) of wet mass powder prepared by different kneading times were quantitatively investigated. Granules (pellets) were then obtained through the extrusion granulation and fluidized bed drying, and the physical properties (strength and disintegration time) of the obtained pellet were evaluated. The relationship between the granule (pellet) physical properties and the mechanical and rheological (rheo-mechanical) properties was analyzed.
- 公益社団法人日本薬学会の論文
- 2003-07-01
著者
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Watano Satoru
Department of Chemical Engineering, Graduate School of Engineering, Osaka Prefecture University
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Watano S
Osaka Prefecture University
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Watano Satoru
Department Of Chemical Engineering Osaka Prefecture University
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Watano Satoru
Department Of Chemical Engineering Graduate School Of Engineering Osaka Prefecture University
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Ohnishi Yasuharu
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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YOSHIKAWA Tomoko
Department of Industrial Chemistry, Faculty of Engineering, Seikei University
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Yoshikawa T
Institute For Medicinal Resources University Of Tokushima
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OSAKO Yoshifumi
Research and Development Department, Fuji Paudal Co., Ltd.
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TSUHARI Masamitsu
Research and Development Department, Fuji Paudal Co., Ltd.
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Ohnishi Y
Pharmaceutical Research Lab. Taiho Pharmaceutical Co. Ltd.
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Yoshikawa T
Kitasato Univ. Kanagawa Jpn
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Yoshikawa Tomoko
Department Of Biology University Of Virginia
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Tsuhari Masamitsu
Research And Development Department Fuji Paudal Co. Ltd.
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Yoshikawa Tetsushi
Laboratory Of Virology Research Institute For Disease Mechanism And Control Nagoya University Graduate School Of Medicine
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