The 5-HT^<2C/2B> Receptor Agonist m-Chlorophenylpiperazine(mCPP)Inhibits 2-Deoxy-D-glucose(2-DG)-Induced Hyperphagia in Rats

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概要

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• Effects of the 5-HT_<2C/2B> receptor agonist m-chlorophenylpiperazine(mCPP)on hyperphagia elicited by 2-deoxy-D-glucose(2-DG)were investigated in rats. mCPP apparently reduced 2-DG-induced hyperphagia. Suppressive effects of mCPP on hyperphagia induced by 2-DG were inhibited by the 5-HT_<2A/2B/2C> receptor antagonist, ritanserin, although the 5-HT_<2A> receptor antagonist ketanserin was without effect. Thus, inhibitory effects of mCPP on 2-DG-induced hyperphagia are mediated by the 5-HT_<2C/2B> receptor. Our results demonstrate that mCPP can inhibit the bulimia model, 2-DG-induced hyperphagia.

• 公益社団法人日本薬学会の論文
• 2001-12-01

著者

• 山田 潤

  神戸薬科大学 薬理

• YAMADA Jun

  Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo

• 杉本 由美

  神戸薬科大学、薬理学研究室

• Sugimoto Yoshihiko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• SUGIMOTO Yumi

  Department of Pharmacology, Kobe Pharmaceutical University

• Sugimoto Y

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Pharmaceutical University

• Sugimoto Yumi

  Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O

• Yamada J

  Kobe Pharmaceutical Univ. Kobe Jpn

• YOSHIKAWA Tomoko

  Department of Industrial Chemistry, Faculty of Engineering, Seikei University

• Sugimoto Yoko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• 山田 潤

  Department Of Pharmacology Kobe Pharmaceutical University

• Yoshikawa T

  Institute For Medicinal Resources University Of Tokushima

• NOMA Toshiko

  Department of Pharmacology, Kobe Pharmaceutical University

• Noma Toshiko

  Department Of Pharmacology Kobe Pharmaceutical University

• 杉本 由美

  Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University

• Sugimoto Yumi

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Women's College Of Pharmacy.

• Yamada J

  Lab. Of Pharmacology Dep. Of Clinical Pharmacy Yokohama Coll. Of Pharmacy

• Sugimoto Y

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• Yamada Jun

  Department Of Pharmacology Kobe Pharmaceutical University

• Yoshikawa T

  Kitasato Univ. Kanagawa Jpn

• Yoshikawa Tomoko

  Department Of Biology University Of Virginia

• Yamada Jun

  Department Of Electrical And Electronics Engineering Aichi Institute Of Technology

• Yoshikawa Tetsushi

  Laboratory Of Virology Research Institute For Disease Mechanism And Control Nagoya University Graduate School Of Medicine

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