FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. VI. EFFECTS OF L-ASCORBATE 2-SULFATE ON LIPID METABOLISM IN GUINEA PIGS
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概要
- 論文の詳細を見る
Effects of L-ascorbate 2-sulfate (AAS) on lipid metabolism were studied in guinea pigs maintained on diet I with sufficient L-ascorbic acid (AA) supplement or on diet II without AA supplement. AAS (300 mg/kg) inhibited an increase in serum and liver levels of lipids to a greater degree than AA (175 mg/kg), a reference compound, in hyperlipidemic guinea pigs induced by cholesterol feeding with diets I or II. AAS also induced a decrease in serum and liver levels of lipids in guinea pigs which had been previously maintained for 6 weeks on diet II containing 1.0 % cholesterol. AA administration significantly increased AA level in various organs of animals maintained on both the diets containing cholesterol. It also rectified the AA level lowered by previous maintenance on diet lI containing cholesterol. AAS showed a slight AA replacing effect on the AA level. Both AA and AAS exerted preventive and curative effects on several symptoms due to chronic AA deficiency.
- 社団法人 日本薬理学会の論文
著者
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Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Terada Mamoru
Department Of Electrical Engineering Nagoya University
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WATANABE Yoshinori
Department of Sustainable Resource Science, Faculty of Bioresources, Mie University
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Hayashi Eiichi
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
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Yamada Jun
Department Of Pharmacology Kobe Pharmaceutical University
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Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
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Watanabe Yoshinori
Department Of Cardiovascular Surgery Toho University Omori Medical Center
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WATANABE Yoshinori
Department of Pharmacology. Shizuoka College of Pharmaceutical Sciences
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KUNITOMO Masaru
Department of Pharmacology. Shizuoka College of Pharmaceutical Sciences
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TERADA Mamoru
Department of Pharmacology. Shizuoka College of Pharmaceutical Sciences
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