Effect of 2,4,6-trinitrophenol on catecholamine secretion from perfused bovine adrenal glands.
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概要
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2, 4, 6-Trinitrophenol (PA) evoked a prolonged catecholamine (CA) secretion from perfused bovine adrenal glands. The PA-evoked CA secretion was concentration-dependent, required the presence of extracellular calcium and resulted from a direct action of PA on the chromaffin cells. Furthermore, PA reduced Mg<SUP>2+</SUP>-ATPase activities in the plasma membrane-rich microsome and granule-rich fraction from the adrenal medulla. These results indicate that PA evokes CA secretion through the actions on both the chromaffin cell membranes and Granule membranes.
- 公益社団法人 日本薬理学会の論文
著者
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Yamada Shizuo
Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka
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Hayashi Eiichi
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
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YAMANAKA Kyozo
Department of Pharmacology, Fukui Medical School
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