Copper-induced alteration of muscarinic binding in bovine adrenal medulla.
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概要
- 論文の詳細を見る
In microsomes of bovine adrenal medulla, there were two affinity binding sites for carbamylcholine with a high and a low affinity. Copper (1-10 μM) largely enhanced the affinity of carbamylcholine at the low affinity binding site, with a slight increase in the affinity at the high affinity binding site. On the other hand, copper slightly decreased the binding affinity of pirenzepine and atropine. Thus, low concentrations of copper modulate the muscarinic receptors in the adrenal medulla by selectively increasing agonist affinity.
- 公益社団法人 日本薬理学会の論文
著者
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Muramatsu Ikunobu
Department Of Pharmacology Faculty Of Medicine Kyoto University And Department Of Zoology And Its Ca
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Kigoshi Shigeru
Department Of Pharmacology Fukui Medical School
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YAMANAKA Kyozo
Department of Pharmacology, Fukui Medical School
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