Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors.
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概要
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The affinity and selectivity of a novel spasmolytic agent, tiquizium bromide (HSR-902), for muscarinic receptors were studied by the radioligand binding technique using <SUP>3</SUP>H-quinuclidinyl benzilate. The parameters (K<SUB>j</SUB>, n<SUB>H</SUB>) of HSR-902 obtained from competition experiments in cerebral cortex and heart muscarinic receptors showed that HSR-902 was an atropine-type, nonselective muscarinic antagonist. The affinity of HSR-902 toward the stomach and ileal muscarinic receptors was about 3-4 times more potent than atropine.
- 公益社団法人 日本薬理学会の論文
著者
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Muramatsu Ikunobu
Department Of Pharmacology Faculty Of Medicine Kyoto University And Department Of Zoology And Its Ca
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Ito Yasuo
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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Kato Hideo
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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Ohashi Tetsuo
Research And Development Division Hokuriku Seiyaku Co. Ltd
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MORIKAWA Kouji
Research Laboratories, Hokuriku Seiyaku Co., Ltd.
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Morikawa Kouji
Research and Development Division, Hokuriku Seiyaku, Co., Ltd.
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OHASHI Tetsuo
Research Laboratories, Hokuriku Seiyaku Co., Ltd.
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OSHITA Masafumi
Research Laboratories, Hokuriku Seiyaku Co., Ltd.
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- Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors.