Noncholinergic, nonadrenergic contraction and substance P in rabbit iris sphincter muscle.
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概要
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In the rabbit iris sphincter muscle, electrical transmural stimulation produced fast and slow components of contraction which were markedly attenuated by tetrodotoxin. The fast component was augmented by physostigmine and was abolished by atropine, while the slow component was little affected. Adrenergic and ganglionic blocking agents did not inhibit the slow component. Therefore, the fast component is probably cholinergic, while the slow one is noncholinergic, nonadrenergic in nature. Capsaicin did produce a considerable contractile response, but there was a gradual decline with repetitive application and a tachyphylaxis occurred. Under such conditions the slow but not the fast component was abolished. Substance P and acetylcholine produced the largest contraction, while ATP, histamine, serotonin and noradrenaline produced little or no response. In cold stored preparations, the responses to electrical transmural stimulation and capsaicin were either markedly attenuated or abolished, whereas substance P and acetylcholine produced considerable contractions. Baclofen and theophylline did not inhibit the slow response to electrical transmural stimulation or the response to substance P and capsaicin. Thus, electrical transmural stimulation produces cholinergic and noncholinergic, nonadrenergic contractions in the rabbit iris sphincter muscle and the latter response is considered to be mediated by substance P or a related peptide released from the neural components.
- 公益社団法人 日本薬理学会の論文
著者
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Muramatsu Ikunobu
Department Of Pharmacology Faculty Of Medicine Kyoto University And Department Of Zoology And Its Ca
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Ueda Naoko
Department Of Breast Surgery Cancer Institute Hospital
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Fujiwara Motohatsu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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SAKAKIBARA Yoshihiko
Department of Pharmacology, Faculty of Medicine, Kyoto University
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FUJIWARA Motohatsu
Departments of Pharmacology, Kyoto University, Faculty of Medicine
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MURAMATSU Ikunobu
Departments of Pharmacology, Kyoto University, Faculty of Medicine
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UEDA Naoko
Departments of Ophthalmology, Kyoto University, Faculty of Medicine
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