EFFECTS OF DOPAMINE AND DOPA ON THE ISOLATED RABBIT'S ATRIUM TREATED WITH RESERPINE
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概要
- 論文の詳細を見る
In the foregoing report Matsuo and Tachi (1) showed that though the isolated atrium of rabbit which was beating <I>in vitro</I> took up considerable amounts of <I>nor</I>adrenaline added to the bath fluid, the content of <I>nor</I>adrenaline of the restarted atrium by addition of <I>nor</I>adrenaline did not significantly differ from the reduced content of <I>nor</I>adrenaline of the atrium which was ceased to beat by addition of 10<SUP>-6</SUP> of reserpine. From the results the authors suggested that the restarting effect derived from the pharmacological action of the catecholamine and not from the biochemical binding of catecholamine to the storage site. The role of the dopa-decarboxylase in <I>nor</I>adrenaline synthesis was substantiated with the demonstration of the conversion of dopa and of dopamine to <I>nor</I>adrenaline (2-3). In this report the effects of dopa and dopamine were studied on the spontaneous contraction, transmembrane potentials and content of <I>nor</I>adrenaline in the isolated rabbit's atrium which had been depressed or abolished the spontaneous activity and depleted the content of <I>nor</I>adrenaline by reserpine.
- 公益社団法人 日本薬理学会の論文
著者
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FUJIWARA Motohatsu
Department of Pharmacology, Faculty of Medicine, Kyoto University
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Fujiwara Motohatsu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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TACHI SHUNJI
Department of Pharmacology, Faculty of Medicine, Kyoto University
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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MATSUO TAKAAKI
Department of Pharmacology, Faculty of Medicine, Kyoto University
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