Comparison of Neurogenic Contraction and Relaxation in Canine Corpus Cavernosum and Penile Artery and Vein
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概要
- 論文の詳細を見る
Functional roles of autonomic efferent nerves were compared in the isolated canine corpus cavernosum, penile artery and penile vein that participate in the penile erection by changing blood distribution. Nicotine produced moderate contraction in the arterial strips, but only a slight or no contraction in the corpus and venous strips. The contraction was suppressed or reversed to a relaxation by prazosin. Under α<SUB>1</SUB>-adrenoceptor blockade, relaxations induced by nicotine were in the order of the corpus > artery >> vein. The response was abolished by <I>N</I><SUP>G</SUP>-nitro-L-arginine (L-NA) and restored by L-arginine. The responses to nicotine and exogenous nitric oxide (NO) were abolished by oxyhemoglobin. The relaxant response to transmural electrical stimulation at 5 Hz was greater in the corpus than venous strips treated with prazosin, and it was abolished by L-NA. Contractions caused by nicotine under treatment with L-NA were greater in the artery than in the vein and corpus. Histochemical studies demonstrated nerve fibers containing NO synthase and tyrosine hydroxylase immunoreactivity in the corpus cavernosum, artery and vein. It is concluded that the canine corpus cavernosum, penile artery and penile vein are innervated by adrenergic, vasoconstrictor and nitroxidergic, vasodilator nerves; neurogenic vasodilatation is predominant in the corpus muscle, whereas neurogenic vasoconstriction predominates in the artery. Such a different functioning of the nerves may be responsible for the penile erection.
- 社団法人 日本薬理学会の論文
- 1996-11-01
著者
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Toda Noboru
Department of Pharmacology, Sniga University of Medical Sciences
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OKAMURA Tomio
Department of Pharmacology, Shiga University of Medical Science
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Okamura T
Department Of Pharmacology Shiga University Of Medical Science
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HAYASHIDA Hideshi
Department of Urology,Shiga University of Medical Science
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Hayashida Hideshi
Department Of Pharmacology Shiga University Of Medical Science
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Okamura Tomio
Department Of Pharmacology
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Toda N
Department Of Pharmacology Shiga University Of Medical Science
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Okamura T
Shiga Univ. Medical Sci. Ohtsu Jpn
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Toda Noboru
Department Of Pharmacology Shiga University Of Medical Science
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Tomoyoshi Tadao
Urology Shiga University Of Medical Sciences School Of Medicine
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FUJIMOTO Hiroshi
Urology, Shiga University of Medical Sciences, School of Medicine
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YOSHIDA Kazuhide
Departments of Pharmacology
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Yoshida Kazuhide
Department Of Otolaryngology Faculty Of Medicine Oita University
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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