Comparison of Endothelium-Related Responses to Nucleotides of Dog and Monkey Cerebral Arteries
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概要
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We compared mechanical responses to uridine-5′triphosphate (UTP) and 2-(methylthio)adenosine-5′diphosphate (2MeSADP) of cerebral arteries isolated from dogs and monkeys. In the dog, UTP induced endothelium-independent contraction, whereas 2MeSADP induced endothelium-dependent relaxation that was abolished by NG-nitro-L-arginine (L-NA). In the monkey, both UTP and 2MeSADP induced endothelium-dependent relaxation. L-NA largely inhibited the UTP-induced relaxation whereas it partially inhibited the 2MeSADP-induced relaxation, and both remaining relaxations were abolished by charybdotoxin plus apamin. In conclusion, dog and monkey cerebral arteries respond differentially to UTP and similarly to 2MeSADP; however, involvement of endothelium-derived relaxing factor in the endothelium-dependent relaxation by 2MeSADP is quite different between the two species.
著者
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Okamura Tomio
Department Of Pharmacology
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Tawa Masashi
Department Of Pharmacology Shiga University Of Medical Sciences
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GEDDAWY Ayman
Department of Pharmacology, Shiga University of Medical Sciences
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Shimosato Takashi
Department Of Pharmacology Shiga University Of Medical Sciences
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Imamura Takeshi
Department Of Applied Physics Faculty Of Science Tokyo Institute Of Technology:(present Address) Fuj
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Geddawy Ayman
Department Of Pharmacology Shiga University Of Medical Science
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Tawa Masashi
Department Of Pharmacology Shiga University Of Medical Science
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Shimosato Takashi
Department Of Pharmacology Shiga University Of Medical Science
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Tawa Masashi
Department of Pharmacology, Shiga University of Medical Sciences, Japan
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Okamura Tomio
Department of Pharmacology, Shiga University of Medical Sciences, Japan
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