Inhibition by Adrenomedullin of the Adrenergic Neurogenic Response in Canine Mesenteric Arteries
スポンサーリンク
概要
- 論文の詳細を見る
Adrenomedullin (AM)inhibited the pressor action caused by transmural electrical stimulation in perfused isolated canine mesenteric arteries. The inhibitory potency of AM was greater than that of calcitonin gene-related peptide (CGRP) or proadrenomedullin NH<SUB>2</SUB>-terminal 20 peptide (PAMP). [8-37]CGRP did not affect the inhibitory action of AM, but suppressed the CGRP-induced inhibition. It may be concluded that AM has an ability to inhibit adrenergic neuronal transmission without the mediation of CGRP<SUB>1</SUB> receptors in the peripheral vasculature, and this inhibition partly participates in the potent hypotensive action of AM.
- 社団法人 日本薬理学会の論文
- 1997-03-01
著者
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ZHANG Jian
Department of Cardiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine
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KANGAWA KENJI
National Cardiovascular Center Research Institute
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Zhang Jian-xin
Department Of Cardiovascular Pharmacology Yamagata University School Of Medicine
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Kangawa Kenji
National Cardiovascular Center
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Zhang Jian
Department Of Pharmacology Shiga University Of Medical Science
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Toda Noboru
Department of Pharmacology, Sniga University of Medical Sciences
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OKAMURA Tomio
Department of Pharmacology, Shiga University of Medical Science
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Okamura Tomio
Department Of Pharmacology
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Zhang Jian
Department Of Cardiology Rui Jin Hospital Shanghai Jiao Tong University School Of Medicine
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Toda Noboru
Department Of Pharmacology Shiga University Of Medical Science
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Zhang Jian
Department Of Biology Huaihua College
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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