Relationship between growth and plasma concentrations of ghrelin and growth hormone in juvenile beagle dogs

概要

論文の詳細を見る
Although the release of growth hormone (GH) is known to be regulated mainly by GH-releasing hormone (GHRH) and somatostatin (SRIF) secreted from the hypothalamus, ghrelin also may be involved in GH release during juvenile period. We have examined plasma concentrations of acylated ghrelin, desacyl ghrelin, and GH in juvenile beagle dogs. Plasma acylated and desacyl ghrelin levels changed through aging; however, there was no closely correlation between ghrelin, body weight and circulating GH levels during juvenile period. The increase in body weight was essentially linear until 8 months of age, whereas plasma GH concentrations exhibited bimodal peaks for the meanwhile. The results suggest that ghrelin may not play internal cueing in GH secretion in juvenile beagle dogs.生後2ヶ月から12ヵ月齢のビーグル犬の年齢に伴う体重増加, 血中グレリンおよび血中成長ホルモン(GH)濃度の推移を調べた.体重はほぼ1年で成体に達したが, この間, グレリン分泌は変化したものの, 体重変化やGH分泌と相関しなかった.GH分泌は生後直後と8ヶ月齢の二相性ピークを形成した.