Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis
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概要
- 論文の詳細を見る
The majority of patients with systemic sclerosis (SSc) have gastrointestinal (GI) tract involvement, but therapies using prokinetic agents are usually unsatisfactory. Ghrelin stimulates gastric motility in healthy human volunteers. In this study, we investigated whether ghrelin could improve gastric emptying in patients with gastrointestinal symptoms due to SSc. The study was performed in a randomized, double-blind, placebo-controlled crossover fashion on two occasions. Ten SSc patients with GI tract involvement received an infusion of either ghrelin (5.0 μg/kg) or saline, and gastric emptying rate was evaluated by 13C-acetic acid breath test. Gastric emptying was significantly accelerated by ghrelin infusion in patients with SSc (ghrelin vs. saline: 43.3 ± 11.4 min vs. 53.4 ± 5.4 min, P=0.03). No serious adverse effects were observed. Our results suggest that ghrelin might represent a new therapeutic approach for GI tract involvement in patients with SSc.
- 一般社団法人 日本内分泌学会の論文
著者
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Murayama Toshinori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Yokode Masayuki
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Tada Harue
Department Of Clinical Trial Design And Management Kyoto University Hospital
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Teramukai Satoshi
Department Of Clinical Trial Design And Management Translational Research Center Kyoto University Ho
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Kangawa Kenji
National Cardiovascular Center
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Yoshimura Kenichi
Department Of Biostatistics School Of Health Sciences And Nursing University Of Tokyo
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Mimori Tsuneyo
Department Of Internal Medicine Keio University School Of Medicine
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Akamizu Takashi
Ghrelin Res. Project Dep. Of Experimental Therapeutics Translational Res. Center Kyoto Univ. Hospita
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Yukawa Naoichiro
Department Of Rheumatology And Clinical Immunology Graduate School Of Medicine Kyoto University
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IWAKURA Hiroshi
Ghrelin Research Project, Translational Research Center, Kyoto University Hospital
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Shimizu Akira
Deparment Of Physics Rikkyo University
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Yonezawa Atsushi
Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Faculty of Medicine
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ITO Tatsuya
Department of Antibiotics, Research Institute for Chemobiodynamics, Chiba University
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Akamizu Takashi
Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto 606-8507, Japan
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Ariyasu Hiroyuki
Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto 606-8507, Japan
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Teramukai Satoshi
Department of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Kyoto 606-8507, Japan
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Shimizu Akira
Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto 606-8507, Japan
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Kangawa Kenji
National Cerebral and Cardiovascular Center Research Institute, Osaka 565-8565, Japan
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