Effect of Intraluminal Pressure on the Intimal Thickening in Injured Rabbit Carotid Arteries in an Organ-Culture System
スポンサーリンク
概要
- 論文の詳細を見る
We developed an organ culture system in order to examine the effect of intraluminal pressure on intimal thickening in injured arteries. After endothelial denudation, an excised rabbit common carotid artery was incubated at 37℃ in a glass bottle perfused with Dulbecco's modified Eagle medium containing 10% fetal calf serum at a constant flow rate of 6 ml/h at various static pressure of 60, 95, 130, 165, or 200 cmH_2O. Intimal thickening, which consisted of smooth muscle cells and extracellular matrix, increased in a time- and pressure-dependent manner up to 130 cmH_2O. Excessive pressures (165 and 200 cmH_2O), however, caused necrosis in the media. These results suggest that a rise in intraluminal pressure accelerates intimal thickening in injured arteries.
- 社団法人日本循環器学会の論文
- 1997-07-20
著者
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YOKODE Masayuki
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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KITA Toru
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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HORIUCHI Hisanori
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Kita Toru
Department Of Cardiology Kobe City Medical Center General Hospital
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Tsukada Toyohiro
Sanraku Hospital
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SAKAI Atsushi
Department of Materials Science and Engineerneering, Interdisciplinary Graduate School of Science an
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Yokode Masayuki
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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ISHII Kenji
Department of Obstetrics and Gynecology, Natinal Dfense Medical College
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Cho Mikimaro
Department of Geriatric Medicine, Kyoto University Faculty of Medicine
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Hara Seijiro
Department of Geriatric Medicine, Kyoto University Faculty of Medicine
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Kanai Kazuo
Japan Agricultural Phamaceutical Company
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Ishii Kenji
Department Of Geriatric Medicine Kyoto University Faculty Of Medicine
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Horiuchi Hisanori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Sakai Atsushi
Department Of Biological Science Faculty Of Science Nara Women's University
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Sakai Atsushi
Division Of Molecular Medicine For Adult And Geriatric Diseases Department Of Clinical Bio-regulator
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Ishii Kenji
Department Of Agricultural And Biological Chemistry Nihon University
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Cho Mikimaro
Department Of Geriatric Medicine Kyoto University Faculty Of Medicine
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Hara Seijiro
Department Of Geriatric Medicine Kyoto University Faculty Of Medicine
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Yokode Masayuki
Department Of Clinical Bio-regulatory Science Division Of Molecular Medicine For Adult And Geriatric
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Sakai Atsushi
Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University
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