Magnitude of Sustained Multiple Risk Factors for Ischemic Heart Disease in Japanese Employees : A Case-Control Study
スポンサーリンク
概要
- 論文の詳細を見る
A case-control study was performed to clarify the cause of ischemic heart disease(IHD), such as acute myocardial infarction and angina pectons, in Japanese employees. Among 122,051 workers from 31 industries, 94 cases of IHD were the subjects of the study, and a total of 191 age-matched subjects from the same department, but who did not develop IHD, served as the controls. Compared with the control group, body mass index, blood pressure, fasting plasma glucose, serum total cholesterol and serum triglyceride were significantly higher, and cigarette consumption and serum uric acid also tended to be higher, in the patient group from at least 10 years prior to onset. The frequency of moderate-drinkers tended to be lower in the case group. Electrocardiograms showed that, compared with the control group, the frequency of myocardial ischemia was higher in the case group from 9 years prior to onset and further rapidly increased from 3 years prior. The frequency of subjects with arrhythmia was the same as the control group until 3 years before onset and increased rapidly from 2 years prior. The frequency of subjects with multiple risk factors, particularly obesity, hypertension, hyperlipidemia and hyperglycemia, was consistently higher in the case group compared with the control group from 10 years prior to onset. Conditional logistic regression analysis demonstrated that having more than one risk factor greatly increased the risk; in particular, the combination of 3 or more factors increased the relative risk to 10.56 (95% confidence interval: 3.30-33.78). These findings suggest that a long duration of multiple risks is involved in the onset of IHD in Japanese employees, and that annual ECG monitoring as part of the medical examination was important in the prognosis.
- 社団法人日本循環器学会の論文
- 2000-12-20
著者
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KITA Toru
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Yamashita Shizuya
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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Matsuzawa Yuji
Department of Internal Medicine, Sumitomo Hospital
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NAKAMURA Tadashi
Department of Metabolic Medicine, Osaka University Graduate School of Medicine
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Funahashi Tohru
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
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Funahashi Tohru
Department of Metabolic Medicine, Graduate School of Medicine
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Yamashita Shizuya
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Nakajima Tadahisa
Department Of Metabolic Medicine Osaka University Graduate School Of Medicine
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Kita Toru
Department Of Cardiology Kobe City Medical Center General Hospital
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HISAMICHI Shigeru
Department of Public Health, Environmental Health Science, Tohoku University Graduate School of Medi
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TSUBONO Yoshitaka
Department of Public Health, Tohoku University Graduate School of Medicine
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Tsubono Yoshitaka
Department Of Internal Medicine And Molecular Science Osaka University Graduate School Of Medicine
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Kameda-Takemura Kaoru
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
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Yamamura Taku
Department of Etiology, Research Institute of National Cardiovascular Center
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Yamamura Taku
Department Of Etiology Research Institute Of National Cardiovascular Center:the Group Of The Researc
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Yamamura Taku
Metabolism National Cardiovascular Center
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Yamamura Taku
Research Institute National Cardiovascular Center
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Kameda Kaoru
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University:t
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Kameda Kaoru
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University:t
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Matsuzawa Yuji
Department Of 2nd Internal Medicine Faculty Of Medicine Oaka University
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Hisamichi Shigeru
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Nakamura Tadashi
Department Of Metabolic Medicine Osaka University Graduate School Of Medicine
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Hisamichi Shigeru
Department Of Public Health Tohoku University School Of Medicine:the Group Of The Research For The A
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Kameda-takemura Kaoru
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University:t
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Funahashi Tohru
Department Of Cardiovascular Surgery National Cerebral And Cardiovascular Center
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Yamamura Taku
Department Of Etiology Research Institute Of National Cardiovascular Center:the Group Of The Researc
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Nakamura Tadashi
Department Of Anesthesia Junwakai Memorial Hospital
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Yamashita Shizuya
Department Of Cardiovascular Medicine Juntendo University School Of Medicine
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Nakamura Takahiro
Laboratory For Mathematics National Defense Medical College
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Yamamura Taku
Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute
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