Serum Adiponectin Level as an Independent Predictor of Mortality in Patients With Congestive Heart Failure
スポンサーリンク
概要
- 論文の詳細を見る
Background Congestive heart failure (CHF) is associated with altered energy homeostasis and myocardial inflammation, hypertrophy, and fibrosis. Adiponectin, an insulin-sensitizing adipocytokine, may affect these pathogenic factors, and the circulating adiponectin level may serve as a biological marker of CHF. This study aimed to assess the significance of serum adiponectin as a prognostic marker for Japanese CHF patients. Methods and Results The serum adiponectin levels were compared between 54 (24 ischemic and 30 nonischemic) CHF patients with left ventricular systolic dysfunction and 55 age- and gender-matched control subjects. The CHF patients also underwent simultaneous clinical assessment and measurements for brain natriuretic peptide (BNP) and parameters of lipid or glucose metabolism. Compared with the controls, the CHF patients showed significantly increased serum adiponectin levels [6.7 (4.9-12.6) vs 14.6 (9.7-25.4) μg/ml, p<0.0001]. In the CHF patients, the log-transformed values of the serum adiponectin levels positively correlated with the log-transformed values of the plasma BNP levels (p=0.0003, r=0.48) and inversely correlated with the body mass index (p=0.0006, r=-0.46). Furthermore, an increase in the serum adiponectin level was associated with higher mortality (p<0.05), particularly in the ischemic CHF patients (p<0.005). Conclusions An increase in the circulating adiponectin level was associated with higher mortality in the ischemic CHF patients. Adiponectin may be an informative risk marker for Japanese CHF patients.
- 社団法人日本循環器学会の論文
- 2007-04-20
著者
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Furukawa Yutaka
Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital
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KITA Toru
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Tamura Toshihiro
Department of Cardiovascular Medicine, Kyoto University Hospital
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Kimura Takeshi
Department of Cardiovascular Medicine, Kyoto University Hospital
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Nakagawa Yoshihisa
Department of Cardiology, Tenri Hospital
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TANIGUCHI Ryoji
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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HORIUCHI Hisanori
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Nakagawa Yoshihisa
behalf of the j-Cypher Registry Investigators
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Tamura Toshihiro
Department Of Cardiology Tenri Hospital
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Nakagawa Yoshihisa
Department Of Cardiology Tenri Hospital
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Furukawa Yutaka
Department Of Cardiology Kobe City Medical Center General Hospital
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ONO Koh
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Kita Toru
Department Of Cardiology Kobe City Medical Center General Hospital
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Sato Yukihito
Department of Cardiovasucular Medicine, Hyogo Prefectural Amagasaki Hospital
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Sato Yukihito
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Ono Koh
Dep. Of Cardiovascular Medicine Graduate School Of Medicine Kyoto Univ. 54 Kawahara-cho Shogoin Saky
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Ono Koh
京都大学 医学研究科循環器内科学
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Ono Koh
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Ono Koh
National Hospital Organization And Department Of Cardiovascular Medicine Graduate School Of Medicine
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Tamura Toshihiro
Department Of Cardiovascular Medicine Kyoto University
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Sato Yukihito
Department Of Cardiovascular Medicine Hyogo Prefectural Amagasaki Hospital
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Satoh Yukihito
Division Of Cardiology Department Of Internal Medicine Hyogo Prefectural Amagasaki Hospital
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Kimura Takeshi
Department Of Cardiology Kobe City Medical Center General Hospital
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Taniguchi Ryoji
Department Of Cardiovascular Medicine Kyoto University
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Taniguchi Ryoji
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Horiuchi Hisanori
Department Of Cardiovascular Medicine Kyoto University
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Furukawa Yutaka
Department Of Biochemistry And Molecular Biology Saitama University
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Horiuchi Hisanori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Nakagawa Yoshihisa
Department Of Cardiology Kokura Memorial Hospital
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Kawamoto Takahiro
Department Of Geriatric Medicine Graduate School Of Medicine Kyoto University
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Ono Koh
Department Of The Cardiovascular Medicine Kyoto University School Hospital
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Tamura Takashi
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Ono Koh
National Hospital Organization And Department Of Cardiovascular Medicine Graduate School Of Medicine
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Ono Kou
Department Of Cardiovascular Medicine Kyoto University Hospital
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Nakagawa Yoshihisa
Division Of Cardiology Tenri Hospital
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Tamura Toshihiro
Department Of Cardiology Kyoto University School Of Medicine
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Higuchi Hirokazu
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Tamura Toshihiro
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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KIMURA Takeshi
Department of Applied Chemistry and Molecular Science, Faculty of Engineering, Iwate University
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