CONTRACTILE RESPONSES OF ISOLATED DOG MESENTERIC ARTERIES TO ANGIOTENSIN I, II AND III
スポンサーリンク
概要
- 論文の詳細を見る
The addition of angiotensin (Ang-) I, II and III caused a dose-dependent contraction of helically cut strips of dog mesenteric arteries. Tachyphylaxis developed following repeated additions of angiotensins. Average median effective concentrations of Ang-I, II and III were 3.7, 0.8 and 2.5×10<SUP>-8</SUP> M, respectively. Contractile responses to the angiotensins were attenuated to a similar extent by Ang-II antagonists, Sarl Ileu<SUP>8</SUP> Ang-II and Sar<SUP>1</SUP> Ala<SUP>8</SUP> Ang-II, but were unaffected by phentolamine, methysergide and diphenhydramine. The response to Ang-I was significantly reduced by treatment with bradykinin-potentiator B, while the response to Ang-II was not influenced. It may be concluded that Ang-I, II and III produce contractions possibly by activation of same Ang-II receptors and that contractions induced by Ang-I are associated, to some extent, with a conversion to Ang-II in the arterial wall.
- 社団法人 日本薬理学会の論文
著者
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MIYAZAKI Mizuo
Department of Pharmacology, Osaka Medical College
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Toda Noboru
Department of Pharmacology, Sniga University of Medical Sciences
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Toda Noboru
Department Of Pharmacology Shiga University Of Medical Science
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HAYASHI Shigehiro
Department of Pharmacology, Shiga University of Medical Sciences
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Miyazaki Mizuo
Department Of Pharmacoldgy Osaka Medical College
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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HAYASHI Shigehiro
Department of Pharmacology, Faculty of Medicine Kyoto University
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- Preface
- CONTRACTILE RESPONSES OF ISOLATED DOG MESENTERIC ARTERIES TO ANGIOTENSIN I, II AND III
- Purification of L-Glutamate Decarboxylase from Monkey Brain
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