EFFECTS OF RENAL VENOUS PRESSURE ELEVATION ON RENAL HEMODYNAMICS, URINE FORMATION AND RENIN RELEASE
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概要
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Effects of renal venous pressure (RVP) elevation on the renal hemodynamics, urine formation and renin secretion rate (RSR) were studied in the pentobar-bital anesthetized dogs. Gradual increment of RVP produced no changes in RBF and GFR till 30 mmHg but a significant decrease in them at RVP above 35 mmHg. The urine flow response to RVP elevation was divided into two groups: an increased urine flow with an increase of sodium excretion and a decreased urine flow with a decrease of sodium excretion. In the former group, gradual RVP elevation produced a significant increase in U_<Na>V, Na/K ratio and T^C_<H_20> without changes in U_KV and C_<osm>, while the latter group showed a decrease in U_<Na>V, U_KV and T^C_<H_20>. Renin secretion rate (RSR), the product of RPF and renal venous-arterial difference of plasma renin activity, increased significantly as function of RVP elevation. This RSR increment seemed to be independent of changes in RBF, GFR, urine flow, or U_<Na>V and the increased mechanism of RSR was discussed. It is concluded that tubular handling of sodium is not essential but intrarenal baroreceptor mechanism seems to be responsible for renin release in case of RVP elevation.
- 社団法人日本循環器学会の論文
- 1972-07-20
著者
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Kishimoto Taketoshi
Department of Urology Osaka City University Medical School
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MIYAZAKI Mizuo
Department of Pharmacology, Osaka Medical College
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Miyazaki Mizuo
Depts. Of Pharmacology Osaka City Univ. Med. Sch.
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YAMAMOTO KENJIRO
Department of Pharmacology, Osaka City University Medical School
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Kishimoto Taketoshi
Dept. Of Urology Osaka City University Medical School Osaka Japan
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Yamamoto Kenjiro
Osaka City University Medical School
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Maekawa Masanobu
Dept. Of Urology Osaka City University Medical School Osaka Japan
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Maekawa Masanobu
Department Of Urology Osaka City University Medical School
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Yamamoto Kenjiro
Department Of Pharmacology Osaka City University Medical School
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Yamamoto Kenjiro
Department Of Pharmacolory Osaka City University Medical School
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Ueda Juro
Department O Fpharmacology Teikyo University School Of Medicine
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Ueda Juro
Dept. Of Pharm. Osaka City Univ. Medical School
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Ueda Juro
Department Of Pharmacology Osaka City University Medical School
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Ueda Juro
Department Of Pharmacology And Urology Osaka City University Medical School
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Miyazaki Mizuo
Department Of Pharmacoldgy Osaka Medical College
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Yamamoto Kenjiro
Departments Of Pharmacology And Urology Osaka City University Medical School
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Kishimoto Taketoshi
Department Of Pharmacology And Urology Osaka City University Medical School
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Yamamoto Kenjiro
Dept. Of Pharm. Osaka City Univ. Medical School
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Ueda Jiro
The Department Of Pharmacology Osaka City University Medical School
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