Role of Renin-Angiotensin System and Nuclear Factor-kB in the Obstructed Kidney of Rats With Unilateral Ureteral Obstruction
スポンサーリンク
概要
- 論文の詳細を見る
The present study was conducted to elucidate the role of oxidative stress and nuclear factor-κB (NF-κB) in the beneficial effects of angiotensin receptor blockade on obstructive nephropathy. Unilateral ureteral occlusion in rats elicited tubulo-interstitial fibrosis with concomitant macrophage infiltration and increased expression of monocyte chemoattractant protein-1. These changes were accompanied by an induction of renal cortical lipid peroxidation and activation of NF-κB. Both an AT1 antagonist, candesartan, and a NF-κB inhibitor, pyrrolidine dithiocarbamate, markedly attenuated these changes and to a similar extent. These results suggest that the beneficial effects of angiotensin blockade are mediated by the inhibition of oxidative stress and subsequent NF-κB activation in obstructive nephropathy.
- 社団法人 日本薬理学会の論文
- 2002-12-01
著者
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Miura Katsuyuki
Department of Health Science, Shiga University of Medical Science
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Nakatani T
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
大阪市立大学 医学部臓器器官病態外科学
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Nakatani Tatsuya
大阪市立大学 医研究臓器器官病態外
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Kishimoto Taketoshi
Department of Urology Osaka City University Medical School
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Miura Katsuyuki
Department Of Applied Pharmacology And Therapeutics Osaka City University Medical School
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Miura Katsuyuki
大阪市立大学 医分子生体医学
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Miura Katsuyuki
大阪市立大学 薬理
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UCHIDA Junji
Department of Urology, Osaka City University Medical School
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Kim T
Seoul National Univ. Seoul Kor
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Kim Taku
大阪市立大学 泌
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Kim Taku
Department Of Urology Osaka City General Hospital
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Okumura M
Ohno Memorial Hospital
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Okumura Michiaki
大阪市立総合医療センター 内科
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Okumura Michiaki
大阪市立大学 薬理
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Uchida J
Department Of Urology Osaka City University
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Uchida J
Duke Univ. Medical Center Nc Usa
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Uchida J
Tokushima Research Center Taiho Pharmaceutical Co. Ltd.
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Uchida Junji
Department Of Immunology Duke University Medical Center
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Miura K
Applied Pharmacology And Therapeutics Osaka City University Medical School
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NAKATAIN Tatsuya
Department of Urology, Osaka City University
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TAMADA Satoshi
Department of Urology, Osaka City University
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ASAI Toshihiro
Department of Urology, Osaka City University
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IWAI Yoshihito
Department of Urology, Osaka City University
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TSUJINO Takashi
Department of Urology, Osaka City University
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KUMATA Norihiko
Department of Urology, Osaka City University
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TASHIRO Koichiro
Department of Urology, Osaka City University
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KUWABARA Nobuyuki
Department of Urology, Osaka City University
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KOMIYA Toshiyuki
Department of Nephrology, Osaka City University
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SUMI Tomohiko
Department of Nephrology, Osaka City University
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OKAMURA Mikio
Department of Nephrology, Osaka City University
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Kim Taku
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
Department Of Biochemistry Kinki University School Of Medicine
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Kaneda Noriko
Department Of Applied Pharmacology And Therapeutics Osaka City University Medical School
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Sugimoto Toshikado
Department Of Urology Osaka City Genaral Hospital
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Tamada S
The Pharmacology And Molecular Biology Rsearch Laboratories Sankyo Co. Ltd.
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Sumi Tomohiko
Department Of Nephrology Osaka City University
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Tamada Satoshi
Department Of Urology Osaka City University Medical School
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Iwai Yoshihito
Department Of Urology Osaka City University
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Asai Toshihiro
Department Of Urology Osaka City University Medical School
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Kim Taku
Department Of Urology Osaka City University
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Kuwabara Nobuyuki
Department Of Urology Osaka City University Medical School
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Tsujino Takashi
Department Of Urology Osaka City University
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Nakatani Tatsuya
Departments Of Pathology And Urology Osaka City University Medical School
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Kuwabara Nobuyuki
Department Of Applied Pharmacology And Therapeutics Osaka City University Medical School
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Uchida J
Department Of Immunology Duke University Medical Center
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Kumata N
Osaka City Univ. Osaka Jpn
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Tashiro Koichiro
Department Of Urology Osaka City University Medical School
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Komiya Toshiyuki
Department Of Medicine The Tazuke Kofukai Medical Research Institute Kitano Hospital
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Kishimoto Taketoshi
Department Of Urology Osaka City University School Of Medicine
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Tashiro Koichiro
Department Of Pharmacology Osaka City University Medical School
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Kishimoto Taketoshi
Department of Urology, Osaka City University Medical School
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TASHIRO Koichiro
Department of Materials Science and Technology, Faculty of Industrial Science and Technology, Science University of Tokyo
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Uchida Junji
Department of Chemistry, Faculty of Science, Hiroshima University
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