Association Between J-Point Elevation and Death From Coronary Heart Disease:– 15-Year Follow-up of the NIPPON DATA90 –
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概要
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Background: An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary heart disease (CHD). Methods and Results: To investigate the association between the presence of J-point elevation ≥0.1mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95% confidence interval [CI] 1.40–4.58; P=0.002) and death from CHD (adjusted HR, 4.66; 95% CI 2.30–9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (≥60 years) (all P for interaction <0.05). Conclusions: J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CHD in a representative sample of the general Japanese population, particularly among the middle-aged.
著者
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YAMAMOTO Takashi
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Ueshima Hirotsugu
Department of Health Science, Shiga University of Medical Science
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Fujiyoshi Akira
Department of Health Science, Shiga University of Medical Science
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Miura Katsuyuki
Department of Health Science, Shiga University of Medical Science
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KITA Yoshikuni
Department of Health Science, Shiga University of Medical Science
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Miura Katsuyuki
Department Of Applied Pharmacology And Therapeutics Osaka City University Medical School
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Kita Yoshikuni
Department Of Health Science Shiga University Of Medical Science
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Ueshima Hirotsugu
Department Of Health Sceicne Shiga University Of Medical Science
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Ohkubo Takayoshi
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Takashima Naoyuki
Department Of Epidemiology National Cardiovascular Center
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Horie Minoru
Department Of Cardiac Physiology National Cardiovascular Center Research Institute
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Fujiyoshi Akira
Department Of Health Science Shiga University Of Medical Science
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Okamura Tomonori
Department Of Cardiology National Cardiovascular Center
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Kadota Aya
Department Of Health Science Shiga University Of Medical Science
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Hisamatsu Takashi
Department Of Cardiology Nagahama Red Cross Hospital
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Murakami Yoshitaka
Department Of Health Science Shgia University Of Medical Science
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Yamamoto Takashi
Department Of Applied Chemistry Faculty Of Engineering Ehime University
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Okayama Akira
First Institute for Health Promotion and Health Care
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Miyagawa Naoko
Department of Health Science, Shiga University of Medical Science
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Nagasawa Shin-ya
Department of Epidemiology and Public Health, Kanazawa Medical University
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