Environmental Factors and Risk of Idiopathic Dilated Cardiomyopathy : A Multi-Hospital Case-Control Study in Japan

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概要

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• Background Detailed epidemiological investigations on the relationship of environmental factors, especially occupational and microbiological factors, to the development of idiopathic dilated cardiomyopathy (IDC) are scarce. Methods and Results A multi-hospital case-control study was conducted in 38 hospitals throughout Japan in order to survey IDC cases and age, sex-matched outpatient controls at each hospital. Crude and adjusted odds ratios (ORs) by various environmental factors were calculated in 135 pairs of cases and controls. Univariate analyses revealed significantly increased ORs for lower education, passive smoking in the workplace, cold and/or hot workplace, symptoms of fatigue and history of bacterial infection; in contrast, decreased ORs were associated with a history of rubella and gastroduodenal diseases. Based on multivariate adjusted analyses, lower education (OR 1.96, 95% confidence interval (CI) 1.13-3.40), cold or hot workplace (OR 1.84, 95%CI 1.08-3.12) and history of measles (OR 1.78, 95%CI 1.01-3.08) exhibited a significant positive relationship with IDC risk. History of rubella (OR 0.17, 95%CI 0.06-0.52) and gastroduodenal diseases (OR 0.14, 95%CI 0.07-0.29) were inversely related to the risk. Conclusions Some occupational and microbiological factors appear to relate independently to the development of IDC and further investigation is required to establish their respective mechanisms.

• 社団法人日本循環器学会の論文
• 2004-10-20

著者

• Toshima H

  The Third Department Of Medicine Kurume University School Of Medicine

• Miura Katsuyuki

  Department of Health Science, Shiga University of Medical Science

• Ito Yoshinori

  札幌医科大学 医学部公衆衛生学

• TOYOSHIMA Hideaki

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in He

• Ito Yoshinori

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• Nakagawa Hideaki

  Department of Epidemiology and Public Health, Kanazawa Medical University

• Toshima Hironori

  The 3rd Department Of Medicine Kurume University School Of Medicine

• MORIKAWA Yuko

  Department of Public Health, Kanazawa Medical University

• Toshima Hironori

  Department Of Public Health Nagoya University Graduate School Of Medicine

• Nishijo M

  Department Of Public Health Saitama Medical School

• INABA Yutaka

  Juntendo University School of Medicine

• 三浦 克之

  Dep. Of Health Sci. Shiga Univ. Of Medical Sci.

• Miura Katsuyuki

  Department Of Applied Pharmacology And Therapeutics Osaka City University Medical School

• Miura Katsuyuki

  Dep. Of Social Medicine Shiga Medical Univ.

• NAGAI Masaki

  Department of Public Health, Saitama Medical School

• Inaba Yutaka

  Juntendo Univ. Tokyo Jpn

• Inaba Yutaka

  Department Of Neurosurgery School Of Medicine Tokyo Medical:dental University

• Inaba Yutaka

  愛知医科大学 公衆衛生学

• Inaba Yutaka

  Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine

• Toyoshima Hideaki

  Department Of Medical Cardiology National Cardiovascular Center

• Ohno Y

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• Ohno Yoshiyuki

  名古屋大学 医学系研究科予防医学

• Hamajima N

  Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua

• Obata Yuki

  愛知医科大学 公衆衛生学

• Obata Yuki

  Department Of Public Health Aichi Medical University School Of Medicine

• Nagai Masaki

  Department Of Aeronautics And Astronautics University Of Tokyo

• Kodama Kazunori

  Department of Epidemiology, Radiation Effect Research Foundation

• Ohno Yoshiyuki

  Asahi Rosai Hospital

• Katsuyama Kazuaki

  Department Of Epidemiology Radiation Effect Research Foundation

• Kodama Kazunori

  Department Of Clinical Studies Radiation Effects Research Foundation

• Nakagawa H

  Department Of Public Health Kanazawa Medical University

• Toyomasu Hiroyuki

  2nd Surgery Kurume University School Of Medicine

• Nishijo Muneko

  Department Of Public Health Kanazawa Medical University

• Inaba Y

  Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine

• Nakagawa Hideaki

  Department Of Epidemiology And Public Health Kanazawa Medical University

• Nagai Masaki

  Department Of Epidemiology And Public Health Kanazawa Medical University

• Morikawa Yuko

  Department Of Public Health Kanazawa Medical University

• Katsuyama Kazuaki

  Yokaichi Public Health Center Prefectural Government Of Shiga

• Toyomasu Hiroyuki

  The Third Dpt Of Internal Of Medicine Kurume University School Of Medicine

• Toschima Hironori

  1st Medical Clinic Kyushu University

• Inaba Yutaka

  Department Of Epidemiology And Enivironmental Health Juntendo University School Of Medicine

• Kodama Kazunori

  Department Of Clinical Studies Radiation Effect Research Foundation

• Toshima Hironori

  The Third Department Of Internal Medicine Kurume University School Of Medicine

• Morikawa Yuko

  Department Of Epidemiology And Public Health Kanazawa Medical University

• Kawado Miyuki

  Laboratory For Genotyping Development Center For Genomic Medicine Riken

• Nakagawa Hideaki

  Department of Clinical Chemistry, Faculty of Pharmaceutical Sciences, Toho University

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