Di-n-butyl Phthalate is Toxic to the Male Reproductive System and Its Toxicity is Enhanced by Thioacetamide Induced Liver Injury
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概要
- 論文の詳細を見る
The modifying effects of liver injury on male reproductive organ toxicity of di-n-butyl phthalate (DBP) were studied using male F344 rats. Seventy-two male animals, aged 10 weeks at the commencement, were divided into 8 groups of 9 rats each. Groups 1 to 4 were given 200 mg/kg bw of thioacetamide (TAA) intraperitoneally 3 times / week, while Groups 5 to 8 were injected with the PBS vehicle only. From 1 week after the start, groups 1 and 5, 2 and 6, and 3 and 7 were given daily 500, 125, 31.25 mg/kg bw of DBP, respectively (23 times) for 4 weeks, while groups 4 and 8 served as vehicle controls. As the result of our treatment, liver injury was induced in the animals, and the liver injury was confirmed by histopathological findings and serum transaminase levels at sacrifice. Enhancement of rat male reproductive organ toxicity of DBP under liver injury status was also seen. The relative organ weights of prostate, bilateral seminal vesicles, bilateral epididymides and bilateral testes, and the sperm number and motility rate were decreased. Also the sperm abnormality rate was increased under liver injury. Furthermore histopathological abnormality of the testis, such as absence of germ cells and the presence of Sertoli cells only was seen in the rats treated with TAA and high dose of DBP, however neither the serum nor testicular testosterone levels varied in the present study. The sperm number and relative weight of bilateral epididymides were decreased by TAA treatment only, unrelated to DBP treatment. These facts suggest that liver injury can not only enhance the rat male reproductive organ toxicity of DBP, but also induce such toxicity by itself.
- 日本毒性病理学会の論文
- 2004-09-30
著者
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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WANIBUCHI Hideki
Department of Pathology, Osaka City University Medical School
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MORIMURA Keiichirou
Department of Pathology, Osaka City University Medical School
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Nakatani Tatsuya
Department of Urology, Osaka City University Medical School
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Fukushima S
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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MITSUHASHI Makoto
Department of Pathology, Osaka City University Medical School
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WADA Seiji
Department of Urology, Osaka City University Medical School
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Mitsuhashi Makoto
Department Of Pathology Osaka City University Medical School
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Nakatani T
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
大阪市立大学 医学部臓器器官病態外科学
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Nakatani Tatsuya
大阪市立大学 医研究臓器器官病態外
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Wanibuchi Hideki
Department Of Pathology Osaka City University Medical School
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Wanibuchi Hideki
大阪府立成人病センター 分子生物学
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Morimura K
Department Of Pathology Osaka City University Medical School
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Morimura Keiichirou
大阪市立大学 医学部都市医学
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Morimura Keiichirou
Department Of Pathology Osaka City University Medical School
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Wada Seiji
Department Of Urology Osaka City University Medical School
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Wada Seiji
大阪市立大学 医学部病理学
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Hayashi S
Department Of Pathology Tokyo Metropolitan Komagome Hospital
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Horiguchi Shinichiro
鳥取大学 医学部病態解析医学講座医用放射線学
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HAYASHI Shin-ichi
Saitama Cancer Center Research Institute
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HAYASHI Shuji
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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Hayashi S
Department Of Pathology Osaka City University Medical School
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KIYOTA Atsuhiko
Department of Urology, Osaka City University Medical School
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Hayashi Shuji
Department Of Neurosurgery Fukuoka University Faculty Of Medicine
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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Wanibuchi H
Department Of Pathology Osaka City University Medical School
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Kiyota Atsuhiko
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
Department Of Biochemistry Kinki University School Of Medicine
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Horiguchi Shinichiro
Department Of Pathology Tokyo Metropolitan Cancer And Infectious Disease Center Komagome Hospital
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Kiyota Atsuhiko
Department Of Pathology Osaka City University Medical School
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Wada Seiji
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Nakatani Tatsuya
Departments Of Pathology And Urology Osaka City University Medical School
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Wanibuchi Hideki
Department Of Pathology Osaka City University Graduate School Of Medicine
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Hayashi Shuji
Department of Cardiovascular Medicine, Tokushima University Hospital, Japan
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