Differences in Sensitivity of F344 Rats from Different Breeders to Phenobarbital Hepatocarcinogenicity

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概要

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• To examine potential variations in sensitivity of F344 rats from different breeders to carcinogens, groups of forty 6-week-old males from CLEA Inc., SLC Co., USA Charles River Co., and Japan Charles River Co. were initially given a single dose (200 mg/kg) of diethylnitrosamine (DEN) i.p., and 2 weeks later, they were given phenobarbital (PB) at a dose of 500 ppm. in the diet for 6 weeks and then sacrificed; all rats being subjected to two-thirds partial hepatectomy (PH) at week 3. Numbers and areas per cm2 of preneoplastic lesions, glutathione S-transferase placental form (GST-P) positive foci in the liver in this Ito test, were increased significantly in PB treated rats from all breeders compared with the corresponding control groups given DEN alone. The number of GST-P positive foci in animals from CLEA Japan, however, increased more than in rats from the other breeders. Assessment with Affymetrix Rat Genome 230 2.0 cDNA microarrays, revealed common changes in expression of genes between treated and control group rats from all sources. Hierarchical cluster analysis revealed the gene expression pattern to be quite similar for rats from USA Charles River Co. and Japan Charles River Co. Although the differences are very subtle, sensitivity of F344 rats to carcinogens may vary depending on breeders.

• 日本毒性病理学会の論文
• 2006-03-01

著者

• HAGIWARA Akihiro

  DIMS Institute of Medical Science, Inc.

• FUKUSHIMA Shoji

  Department of Pathology, Osaka City University Medical School

• WANIBUCHI Hideki

  Department of Pathology, Osaka City University Medical School

• KANG JIN

  Department of Pediatrics, The Catholic University of Korea

• Hagiwara A

  Dims Institute Of Medical Science Inc.

• Hagiwara Akihiro

  Dims医科学研究所

• Hagiwara Akihiro

  大阪市立大学 医学部病理学第1

• Hagiwara Akihiro

  Dims Inst. Medical Sci. Inc.

• SEKI Shuichi

  Department of Hepatology, Graduate School of Medicine, Osaka City University

• Wanibuchi Hideki

  Department Of Pathology Osaka City University Medical School

• Wanibuchi Hideki

  大阪府立成人病センター 分子生物学

• Wanibuchi Hideki

  大阪市立大学 核医

• Wanibuchi Hideki

  Dept. Pathology Osaka City University Medical School

• Kang Jin

  Department Of Pathology Osaka City University Medical School

• HAGIHARA Atsushi

  Department of Pathology, Osaka City University Medical School

• PUATANACHOKCHAI Rawiwan

  Department of Pathology, Osaka City University Medical School

• MIYAZI Natsuko

  Department of Pathology, Osaka City University Medical School

• Seki Shuichi

  Department Of Cardiology Chikamori Hospital

• Kang Jin

  Department Of Biomedical Laboratory Science Namseoul Univeristy

• Fujiwara Yushi

  Department Of Surgery Osaka City Juso Hospital

• Miyazi Natsuko

  Department Of Pathology Osaka City University Medical School

• Wanibuchi H

  Department Of Pathology Osaka City University Medical School

• Puatanachokchai Rawiwan

  Department Pathology Osaka City University Medical School

• Puatanachokchai Rawiwan

  Department Of Oncological Pathology Cancer Center Nara Medical University

• Seki Shuichi

  Department Of Hepatology Osaka City University Medical School

• Fujiwara Yushi

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

• Fukushima Shoji

  Japan Bioassay Research Center Japan Industrial Safety And Health Association

• Fukushima Shoji

  中央労働災害防止協会日本バイオアッセイ研究センター

• Fukushima Shoji

  Japan Bioassay Research Center

• Fukushima Shoji

  Dept. Pathol. Osaka City University Medical School

• Fukushima Shoji

  Department Of Pathology Osaka City University Medical School

• Hagihara Atsushi

  Department Of Pathology Osaka City University Medical School

• Fukuhara Kennichirou

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

• Kang Jin

  Department Of Anesthesiology And Pain Medicine Samsung Medical Center Sungkyunkwan University School

• Hagiwara Akihiro

  First Department Of Pathology Nagoya City University Medical School

• Fukushima Shoji

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

• Fukushima Shoji

  Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.

• Wanibuchi Hideki

  Department Of Pathology Osaka City University Graduate School Of Medicine

• Hagihara Atsushi

  Department of Hepatology, Osaka City University Hospital, Japan

• HAGIHARA Atsushi

  Department of Hepatology, Osaka City University Graduate School of Medicine

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