Lack of Enhanced Epithelial Cell Proliferation in the Urinary Bladder of Heterozygous p53 Knockout Mice Given Sodium Ortho-phenylphenate or Uracil

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概要

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• In the present study, we investigated epithelial cell proliferation in heterozygous p53 knockout (p53+/-) mice after administration of two urinary bladder non-genotoxic carcinogens, in comparison with that in wild-type littermates (p53+/+). Mice at 10-weeks of age were given 2% sodium ortho-phenylphenate (Na-OPP) or 2.5% uracil in the basal diet for 4 weeks. Uracil evoked a marked elevation of epithelial cell proliferation and development of papillary or diffuse epithelial hyperplasia associated with calculus formation in p53+/- as well as p53+/+ mice. Administration of Na-OPP caused alkalization of the urine in both. Neither Na-OPP nor uracil induced a higher epithelial cell proliferative response in p53+/- mice as compared with p53+/+ mice. While we previously reported p53+/- mice to be highly sensitive to a genotoxic urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine, the present results suggest that p53+/- mice may not have a high susceptibility to induction of urinary bladder tumors by non-genotoxic carcinogens.

• 日本毒性病理学会の論文
• 2003-09-30

著者

• FUKUSHIMA Shoji

  Department of Pathology, Osaka City University Medical School

• OKUNO Yasuyoshi

  Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.

• Sukata Tokuo

  Environmental Health Science Lab. Sumitomo Chemical Co. Ltd.

• Fujiwara Yushi

  Department Of Surgery Osaka City Juso Hospital

• Uwagawa Satoshi

  Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Fujiwara Yushi

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

• Fukushima Shoji

  Japan Bioassay Research Center Japan Industrial Safety And Health Association

• OZAKI Keisuke

  Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.

• KUSHIDA Masahiko

  Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.

• Fukushima Shoji

  Department Of Pathology Osaka City University Medical School

• Kushida Masahiko

  Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Okuno Yasuyoshi

  Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Fukushima Shoji

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

• Fukushima Shoji

  Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.

• Uwagawa Satoshi

  Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Ozaki Keisuke

  Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Sukata Tokuo

  Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Kushida Masahiko

  Department Of Pathology Osaka City University Medical School

• Okuno Yasuyoshi

  Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd

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