Lack of Enhanced Epithelial Cell Proliferation in the Urinary Bladder of Heterozygous p53 Knockout Mice Given Sodium Ortho-phenylphenate or Uracil
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, we investigated epithelial cell proliferation in heterozygous p53 knockout (p53+/-) mice after administration of two urinary bladder non-genotoxic carcinogens, in comparison with that in wild-type littermates (p53+/+). Mice at 10-weeks of age were given 2% sodium ortho-phenylphenate (Na-OPP) or 2.5% uracil in the basal diet for 4 weeks. Uracil evoked a marked elevation of epithelial cell proliferation and development of papillary or diffuse epithelial hyperplasia associated with calculus formation in p53+/- as well as p53+/+ mice. Administration of Na-OPP caused alkalization of the urine in both. Neither Na-OPP nor uracil induced a higher epithelial cell proliferative response in p53+/- mice as compared with p53+/+ mice. While we previously reported p53+/- mice to be highly sensitive to a genotoxic urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine, the present results suggest that p53+/- mice may not have a high susceptibility to induction of urinary bladder tumors by non-genotoxic carcinogens.
- 日本毒性病理学会の論文
- 2003-09-30
著者
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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OKUNO Yasuyoshi
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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Sukata Tokuo
Environmental Health Science Lab. Sumitomo Chemical Co. Ltd.
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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Uwagawa Satoshi
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Fujiwara Yushi
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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OZAKI Keisuke
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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KUSHIDA Masahiko
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Kushida Masahiko
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Okuno Yasuyoshi
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
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Uwagawa Satoshi
Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Ozaki Keisuke
Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Sukata Tokuo
Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Kushida Masahiko
Department Of Pathology Osaka City University Medical School
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Okuno Yasuyoshi
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd
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