FENVALERATE-INDUCED GRANULOMATOUS CHANGES IN RATS AND MICE
スポンサーリンク
概要
- 論文の詳細を見る
Wistar rats and ddY mice were fed diet containing 10 to 3000 ppm technical fenvalerate for the major portion of their life span. Microgranulomatous changes were observed in lymph nodes, liver and spleen of both rats and mice as well as in adrenals of rats. The no-effect level for microgranulomatous changes was 30 ppm for mice and 150 ppm for rats. Transmission electron microscopy of phagocytes in the granulomatous foci revealed needleor rod-shaped crystalline bodies within the cytoplasm. To examine reversibility of the microgranulomatous changes, ddY mice were fed the diet containing technical fenvalerate at the levels of 1000 and 3000 ppm for 6 weeks, followed by rearing on the control diet for up to 12 months. The size and number of the microgranulomatous changes were reduced with time. The microgranulomatous changes were typical of foreign body granulomas; they did not have the appearance of granulomas formed in response to immunologic stimulus.
- 日本トキシコロジー学会の論文
- 1986-02-25
著者
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Seki Takaki
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Sukata Tokuo
Environmental Health Science Lab. Sumitomo Chemical Co. Ltd.
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OKUNO Yasuyoshi
Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
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ITO Seiichi
Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
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SEKI Takaki
Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
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HIROMORI Toshihiko
Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
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MURAKAMI Masakazu
Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
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KADOTA Tadaomi
Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
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MIYAMOTO Junshi
Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
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Ito S
Yamanouchi Pharmaceutical Co. Ltd. Tokyo Jpn
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Kadota Tadaomi
Laboratory Of Biochemistry And Toxicology Takarazuka Research Center Sumitomo Chemical Co. Ltd.
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MURAKAMI Masakazu
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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Okuno Yasuyoshi
Environmental Health Science Laboratory Sumitomo Chemical Company Ltd.
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MIYAMOTO Junshi
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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Murakami M
Univ. Tokyo Tokyo
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Miyamoto J
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Hiromori Toshihiko
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Sukata Tokuo
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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