Spontaneous Iron Accumulation in Hepatocytes of a 7-Week-Old Female Rat
スポンサーリンク
概要
- 論文の詳細を見る
Spontaneous iron accumulation in hepatocytes was observed in a 7-week-old female Han Wistar GALAS rat. Very fine yellowish brown pigments, which showed a positive reaction with Berlin Blue stain, were apparent in the cytoplasm close to the bile canaliculi, with a diminishing periportal-to-centrilobular gradient. There were also differences in distribution between and within lobes. Transmission electron microscopy revealed cytosolic ferritin and pericanalicular siderosomes in hepatocytes. No degeneration or necrotic changes were observed, and non-hepatocyte cells did not demonstrate any obvious accumulation of iron. There were no abnormalities in the animal other than this finding in the liver.
- 日本毒性病理学会の論文
著者
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Sukata Tokuo
Environmental Health Science Lab. Sumitomo Chemical Co. Ltd.
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Miyata Kaori
Environmental Health Science Laboratory Sumitomo Chemical Company Ltd.
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Uwagawa Satoshi
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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OZAKI Keisuke
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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Kushida Masahiko
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Ogata Keiko
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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Suzuki Manabu
Animal Clinic Support Center, Sumika Technoservice Corporation
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Ozaki Masakazu
Animal Clinic Support Center, Sumika Technoservice Corporation
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