Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker

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概要

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• Epidemiological studies suggest that alcohol consumption increases the risk of developing colorectal cancer. However, the data are confounded by numerous cosegregating variables. To cast further light on the relationships between alcohol intake and colon cancer development, 21-day-old male F344/DuCrj rats were fed 200 ppm 2-amino-3,8-dimethylimidazo[4,5-<i>f</i>]quinoxaline (MeIQx) in their diet for 8 weeks and doses of 0, 0.1, 0.3, 1, 3, 10 and 20% of ethanol in their drinking water <i>ad libitum</i> for 16 weeks thereafter. The rats were sacrificed after 24 weeks of experiment, and aberrant crypt foci (ACF), surrogate lesions for colon cancer, were examined under a light microscope at low magnification. Ethanol was found not to affect the ACF formation at any dose compared with the initiated-controls. Furthermore, ethanol did not alter colon epithelial cell proliferation. These data, obtained by analysis of a colon cancer surrogate marker lesion, indicate that ethanol lacks promotion activity for MeIQx-initiated rat colon carcinogenesis. <br>

• 日本毒性病理学会の論文
• 2009-03-01

著者

• Fukushima S

  Japan Bioassay Research Center Japan Industrial Safety And Health Association

• Wanibuchi Hideki

  大阪府立成人病センター 分子生物学

• Wanibuchi Hideki

  大阪市立大学 核医

• Wanibuchi Hideki

  Dept. Pathology Osaka City University Medical School

• Ogata Keiko

  Pathology and Clinical Science Group, Environmental Health Science Laboratory, Sumitomo Chemical Co.

• Kinoshita Anna

  Department Of Pathology Osaka City University Medical School

• Kushida Masahiko

  Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect

• Fukushima Shoji

  中央労働災害防止協会日本バイオアッセイ研究センター

• Wei Min

  Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine

• Kushida Masahiko

  Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Fukuhara Kennichirou

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

• Min Wei

  Department Of Pathology Osaka City University Medical School

• Fukushima Shoji

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

• Kakehashi Anna

  Department Of Pathology Osaka City University Medical School

• Wanibuchi Hideki

  Department Of Pathology Osaka City University Graduate School Of Medicine

• Uwagawa Satoshi

  Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Miyata Kaori

  Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Ozaki Keisuke

  Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Sukata Tokuo

  Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

• Kushida Masahiko

  Department Of Pathology Osaka City University Medical School

• Ogata Keiko

  Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.

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