Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker
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概要
- 論文の詳細を見る
Epidemiological studies suggest that alcohol consumption increases the risk of developing colorectal cancer. However, the data are confounded by numerous cosegregating variables. To cast further light on the relationships between alcohol intake and colon cancer development, 21-day-old male F344/DuCrj rats were fed 200 ppm 2-amino-3,8-dimethylimidazo[4,5-<i>f</i>]quinoxaline (MeIQx) in their diet for 8 weeks and doses of 0, 0.1, 0.3, 1, 3, 10 and 20% of ethanol in their drinking water <i>ad libitum</i> for 16 weeks thereafter. The rats were sacrificed after 24 weeks of experiment, and aberrant crypt foci (ACF), surrogate lesions for colon cancer, were examined under a light microscope at low magnification. Ethanol was found not to affect the ACF formation at any dose compared with the initiated-controls. Furthermore, ethanol did not alter colon epithelial cell proliferation. These data, obtained by analysis of a colon cancer surrogate marker lesion, indicate that ethanol lacks promotion activity for MeIQx-initiated rat colon carcinogenesis. <br>
- 日本毒性病理学会の論文
- 2009-03-01
著者
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Fukushima S
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Wanibuchi Hideki
大阪府立成人病センター 分子生物学
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Wanibuchi Hideki
大阪市立大学 核医
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Wanibuchi Hideki
Dept. Pathology Osaka City University Medical School
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Ogata Keiko
Pathology and Clinical Science Group, Environmental Health Science Laboratory, Sumitomo Chemical Co.
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Kinoshita Anna
Department Of Pathology Osaka City University Medical School
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Kushida Masahiko
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Wei Min
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Kushida Masahiko
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Min Wei
Department Of Pathology Osaka City University Medical School
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Kakehashi Anna
Department Of Pathology Osaka City University Medical School
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Wanibuchi Hideki
Department Of Pathology Osaka City University Graduate School Of Medicine
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Uwagawa Satoshi
Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Miyata Kaori
Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Ozaki Keisuke
Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Sukata Tokuo
Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Kushida Masahiko
Department Of Pathology Osaka City University Medical School
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Ogata Keiko
Pathology And Clinical Science Group Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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