Enhanced hepatocarcinogenicity by combined inhalation and oral exposures to N,N-dimethylformamide in male rats
スポンサーリンク
概要
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N,N-Dimethylformamide (DMF), a ubiquitous contaminant in living and working environments, enters the human body by inhalation, as well as by oral and dermal routes of exposure. In order to provide bioassay data for carcinogenic risk assessment of humans exposed to DMF by multiple routes of exposure, hepatocarcinogenic effect of combined inhalation and oral exposures of rats to DMF was examined. A group of 50 male F344 rats, 6-week-old, was exposed by inhalation to 0 (clean air), 200, or 400ppm (v/v) of DMF vapor-containing air for 6hr/day and 5 days/week during a 104-week period, and each inhalation group was given ad libitum DMF-formulated drinking water at 0, 800 or 1,600ppm (w/w) for 104 weeks. Incidences of hepatocellular adenomas and carcinomas and their combined incidences were significantly increased in the combined-exposure groups compared with the untreated control group or each of the inhalation-alone and oral-alone groups with matching concentrations. Incidences of hepatocellular adenomas and carcinomas induced by the combined exposures were greater than the sum of the two incidences of the hepatocellular adenomas and carcinomas induced by the single-route exposures through inhalation and ingestion. The combined exposures enhanced tumor malignancy. It was concluded that the combined inhalation and oral exposures markedly enhance the incidences and malignancy of hepatocellular tumors, suggesting that the hepatocarcinogenic effect of the combined exposures is greater than the effect that would be expected under the assumption that the two effects of single-route exposures through inhalation and drinking are additive.
- 2009-02-01
著者
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Fukushima S
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Ohbayashi Hisao
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Nagano Kasuke
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Fukushima Shoji
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Senoh Hideki
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nagano Kasuke
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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長野 嘉介
Division Of Pathology Japan Bioassay Research Center
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Nagano Kasuke
Japan Bioassay Research Center
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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KANO Hirokazu
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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UMEDA Yumi
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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ARITO Heihachiro
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Kasai Tatsuya
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Arito Heihachiro
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
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Katagiri Taku
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Kano Hirokazu
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Umeda Yumi
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Ohbayashi Hisao
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Ohbayashi Hisao
Japan Bioassay Laboratory Japan Industrial Safety And Health Association
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Nagano K
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Senoh Hideki
Department Of Pathology Japan Bioassay Research Center
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Fujiwara Yushi
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Ohbayashi Hisao
中央労働災害防止協会日本バイオアッセイ研究センター
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Fukushima Shoji
Japan Bioassay Research Center
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Senoh Hideki
中央労働災害防止協会日本バイオアッセイ研究センター
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Kasai Tatsuya
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Kasai Tatsuya
中央労働災害防止協会日本バイオアッセイ研究センター
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長野 嘉介
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
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Nagano Kasuke
中央労働災害防止協会日本バイオアッセイ研究センター
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