Developmental Toxicity Induced by Inhalation Exposure of Pregnant Rats to N,N-Dimethylacetamide
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概要
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Developmental toxicity of N,N-dimethylacetamide (DMAC) was examined by exposing pregnant rats by inhalation to DMAC vapor at 0 (control), 100, 300, 450 or 600ppm (v/v) for6 h/d during Gestation Days 6 through 19. Fetal body weight and the number of male live fetuses were significantly decreased, along with a tendency of the number of intrauterine deaths to increase. The number of fetuses with visceral and skeletal malformations was significantly increased in the 450 and 600ppm groups, while the number of fetuses with anasarca as an external malformation was increased at 600ppm. Observed cardiovascular malformations included ventricular septum defect, persistent truncus arteriosus, malpositioned subclavian branch and retroesophageal subclavian artery. Persistent truncus arteriosus was accompanied by ventricular septal defect (VSD). Incidences of the persistent truncus arteriosus, which was classified as a serious congenital heart disease affecting postnatal survival, were increased at 450 and 600ppm. Increased liver weights and hepatocellular swelling occurred in the dams exposed to 300ppm and above, whereas neither hepatocellular necrosis nor increased serum activity of liver transaminases was observed in any of the exposed groups. Maternal body weights were decreased at 450 and 600ppm. The most sensitive signs of developmental toxicity appeared at the exposure level of 300ppm which was also the level of slight maternal toxicity. The No-Observed-Adverse-Effect-Level (NOAEL) was determined as 100ppm for the endpoints of fetal and maternal toxicities. The NOAEL of 100ppm and the induction of serious cardiovascular malformations occurring at 450ppm and above were discussed with reference to the existing occupational exposure limit for DMAC.
- 社団法人日本産業衛生学会の論文
著者
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MATSUSHIMA Taijiro
Japan Bioassay Research Center
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竹内 哲也
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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OKUDA Hirokazu
Japan Bioassay Research Center. Japan Industrial Safety and Health Association
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Nagano Kasuke
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Senoh Hideki
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nagano Kasuke
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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長野 嘉介
Division Of Pathology Japan Bioassay Research Center
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Nagano Kasuke
Japan Bioassay Research Center
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Yamamoto Seigo
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Okuda Hirokazu
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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ARITO Heihachiro
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Takeuchi Tetsuya
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Arito Heihachiro
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
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Nagano K
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Senoh Hideki
Department Of Pathology Japan Bioassay Research Center
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Senoh Hideki
中央労働災害防止協会日本バイオアッセイ研究センター
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竹内 哲也
Division Of Pathology Japan Bioassay Research Center
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Matsushima Taijiro
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Matsushima Taijiro
Japan Industrial Safety And Health Assoc. Kanagawa Jpn
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Matsushima Taijiro
Japan Bioassay Laboratory
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長野 嘉介
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nagano Kasuke
中央労働災害防止協会日本バイオアッセイ研究センター
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Okuda Hirokazu
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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