Characterization of Hydroxy-biphenyl-O-sulfates in Urine and Urine Crystals Induced by Biphenyl and KHCO_3 Administration in Rats
スポンサーリンク
概要
- 論文の詳細を見る
In order to obtain information on the relationship between calculi and urine-crystal constituents, component analyses of the biphenyl sulfate conjugates in urine and urine crystals in rats fed a diet containing biphenyl and KHCO_3 were performed by LC-MS/MS and FT-IR. LC-MS/MS analysis revealed the presence of biphenyl metabolites, i.e., three isomers of monohydroxy-biphenyl-O-sulfate (HBPOS) and five isomers of dihydroxy-biphenyl-O-sulfate (DHBPOS), in rat urine. The same results were obtained for the crystals in rat urine. These findings suggested that the metabolism of biphenyl resulting in the formation of sulfate conjugates follows the process : biphenyl → monoor dihydroxylation → sulfate conjugation. FT-IR analysis of the urine crystals indicated that the major constituent was the potassium salt of 4-hydroxy-biphenyl-O-sulfate (4-HBPOS), which is known to be the main constituent of urinary bladder calculi. Consequently, in view of the similarity of the major constituent, the potassium salt of 4-HBPOS, in both the urine crystals and calculi, it is thought that the formation of the calculi can be attributed to the lower solubility of the potassium salt of 4-HBPOS, as compared to the other sulfate conjugates.
- 公益社団法人日本薬学会の論文
- 2000-08-01
著者
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MATSUSHIMA Taijiro
Japan Bioassay Research Center
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TAKEMURA TETSUO
Department of Chemistry, Faculty of Sciences, Science University of Tokyo
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Yamamoto Seigo
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Ohnishi Makoto
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Yajima Hirofumi
Department of Applied Chemistry, Faculty of Science, Tokyo University of science
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Ohnishi Makoto
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
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Ohnishi Makoto
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Yajima H
Department Of Applied Chemistry Faculty Of Science Tokyo University Of Science
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Yajima Hirofumi
Department Of Applied Chemistry Faculty Of Science Tokyo University Of Science
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Yajima Hirofumi
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Terada Tohru
RIKEN
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ISHII Tadahiro
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo
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Ishii T
Sumitomo Chemical Co. Ltd. Takarazuka Jpn
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Ishii Tadahiro
Science University Of Tokyo Faculty Of Science
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Ishii Tadahiro
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Terada Tohru
Agricultural Bioinformatics Reserch Unit Graduate School Of Agricultural And Life Sciences Univ. Of
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Matsushima Taijiro
Japan Industrial Safety And Health Assoc. Kanagawa Jpn
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Matsushima Taijiro
Japan Bioassay Laboratory
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Takemura T
Agricultural Bioinformatics Research Unit Graduate School Of Agricultural And Life Sciences The Univ
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Takemura Tetsuo
Department Of Applied Physics Faculty Of Engineering Kyushu University
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Terada Tohru
Agricultural Bioinformatics Reserch Unit Graduate School Of Agricultural And Life Sciences Univ. Of
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Terada Tohru
Agricultural Bioinformatics Reserch Unit Graduate School Of Agricultural And Life Sciences Univ. Of
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