Design and performance of a system for blood collection of rats under whole-body inhalation exposure
スポンサーリンク
概要
- 論文の詳細を見る
In order to obtain basic risk assessment data on human health exposure to volatile organic compound (VOC) vapor by inhalation, a whole-body inhalation exposure system which allows blood collection during the exposure period was designed. The system was tested using chloroform as a model VOC. Chloroform vapor, sampled from the supply-header, animal-chambers and exhaust-header, remained constant in this system with variations in its concentration being less than 2%; flow rate of the vapor through the system was also constant. Rats were exposed to chloroform vapor and blood collected from the tail during exposure to the chloroform vapor. The chloroform concentration in the blood increased during the initial 60min of exposure, and afterwards its concentration remained at about 2μg/ml from 60 to 360min. In conclusion, our design allows blood to be collected from individual rats during exposure by inhalation to test VOCs and changes in the blood concentration of the VOC during exposure to be assessed.
- 日本トキシコロジー学会の論文
- 2009-04-01
著者
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Fukushima S
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nagano Kasuke
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Fukushima Shoji
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Nagano Kasuke
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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長野 嘉介
Division Of Pathology Japan Bioassay Research Center
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Nagano Kasuke
Japan Bioassay Research Center
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Yamamoto Seigo
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Take Makoto
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Ohnishi Makoto
Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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Take Makoto
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Take Makoto
Japan Bioassay Laboratory
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Ohnishi Makoto
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
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Ohnishi Makoto
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nagano K
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Fujiwara Yushi
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Fukushima Shoji
Japan Bioassay Research Center
-
長野 嘉介
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
Fukushima Shoji
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
-
Nagano Kasuke
中央労働災害防止協会日本バイオアッセイ研究センター
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